Analysis of novel Sjogren’s syndrome autoantibodies in patients with dry eyes

BMC Ophthalmology

Research Article

Lakshmanan Suresh¹  Sahana Vishwanath²  Vanessa Cavero²  Julian L. Ambrus³  Sandra Everett⁴  Norah Lincoff-Cohen⁵  Long Shen⁶  Kishore Malyavantham⁶ 

[1] Dental School, SUNY at Buffalo School of Medicine, Buffalo, NY, USA;Immco Diagnostics, Buffalo, NY, USA;Department of Medicine, SUNY at Buffalo School of Medicine, Buffalo, NY, USA;Department of Medicine, SUNY at Buffalo School of Medicine, Buffalo, NY, USA;Division of Allergy, Immunology and Rheumatology, SUNY at Buffalo School of Medicine, Room C281, Buffalo General Hospital, 100 High Street, 14203, Buffalo, NY, USA;Department of Ophthalmology, SUNY at Buffalo School of Medicine, Buffalo, NY, USA;Department of Ophthalmology, SUNY at Buffalo School of Medicine, Buffalo, NY, USA;Department of Neurology, SUNY at Buffalo School of Medicine, Buffalo, NY, USA;Immco Diagnostics, Buffalo, NY, USA;

关键词: Sjogren’s syndrome;    Dry eyes;    Corneal abrasion;    Autoantibodies;   

DOI  :  10.1186/s12886-017-0412-8

 received in 2016-07-19, accepted in 2017-02-11,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundDry eye is a common problem in Ophthalmology and may occur for many reasons including Sjogren’s syndrome (SS). Recent studies have identified autoantibodies, anti-salivary gland protein 1 (SP1), anti-carbonic anhydrase 6 (CA6) and anti-parotid secretory protein (PSP), which occur early in the course of SS.The current studies were designed to evaluate how many patients with idiopathic dry eye and no evidence of systemic diseases from a dry eye practice have these autoantibodies.MethodsPatients from a dry eye clinic and normal controls were assessed by Schirmer’s test for tear flow. Sera were assessed for autoantibodies using ELISA assays. Statistics was performed with Prism 7 software and student’s unpaired t test.ResultsIn this study 60% of the dry eye patients expressed one of these autoantibodies. Only 30% expressed one of the autoantibodies associated with long-standing SS, which are included in the diagnostic criteria for SS, anti-Ro and anti-La. Patients with disease for less than 2 years and mild dry eyes did not express anti-Ro or anti-La, while 25% expressed anti-SP1. Similar observations, with smaller numbers, were made when patients had not only dry eye but also dry mouth.ConclusionsAntibodies to SP1, CA6 and PSP occur in some patients with idiopathic dry eyes. Further studies will be needed to determine how many of these patients go on to develop systemic manifestations of SS. Testing for these autoantibodies may allow early recognition of patients with SS. This will lead to improved management of the patients and the development of new strategies to maintain normal lacrimal and salivary gland function in patients with SS.

【 授权许可】

CC BY   
© The Author(s). 2017