Segmentation error in spectral domain optical coherence tomography measures of the retinal nerve fibre layer thickness in idiopathic intracranial hypertension

BMC Ophthalmology

Research Article

John Horsburgh¹  Susan P Mollan²  Anuriti Aojula³  William J Scotton⁴  Andreas Yiangou⁴  Alexandra J Sinclair⁴  Kiera A Markey⁴  James L Mitchell⁴  Pearse A Keane⁵ 

[1] Birmingham Neuro-Ophthalmology Unit, University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital, Edgbaston, B15 2TH, Birmingham, UK;Institute of Metabolism and Systems Research, University of Birmingham, B15 2TT, Birmingham, UK;Birmingham Neuro-Ophthalmology Unit, University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital, Edgbaston, B15 2TH, Birmingham, UK;Institute of Metabolism and Systems Research, University of Birmingham, B15 2TT, Birmingham, UK;Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, B15 2TH, Birmingham, UK;Institute of Metabolism and Systems Research, University of Birmingham, B15 2TT, Birmingham, UK;Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, B15 2TH, Birmingham, UK;Department of Neurology, University Hospitals Birmingham NHS Foundation Trust, B15 2TH, Birmingham, UK;NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK;

关键词: Papilloedema;    Idiopathic intracranial hypertension;    Pseudotumour Cerebri;    Optical coherence tomography;    Retinal nerve fibre layer;    Artefact;    Imaging;    Monitoring;   

DOI  :  10.1186/s12886-017-0652-7

 received in 2017-06-01, accepted in 2017-12-08,  发布年份 2018

来源: Springer

【 摘 要 】

BackgroundOptical Coherence Tomography (OCT) imaging is being increasingly used in clinical practice for the monitoring of papilloedema. The aim is to characterise the extent and location of the Retinal Nerve Fibre Layer (RNFL) Thickness automated segmentation error (SegE) by manual refinement, in a cohort of Idiopathic Intracranial Hypertension (IIH) patients with papilloedema and compare this to controls.MethodsBaseline Spectral Domain OCT (SDOCT) scans from patients with IIH, and controls with no retinal or optic nerve pathology, were examined. The internal limiting membrane and RNFL thickness of the most severely affected eye was examined for SegE and re-segmented. Using ImageJ, the total area of the RNFL thickness was calculated pre and post re-segmentation and the percentage change was determined. The distribution of RNFL thickness error was qualitatively assessed.ResultsSignificantly greater SegE (p = 0.009) was present in RNFL thickness total area, assessed using ImageJ, in IIH patients (n = 46, 5% ± 0–58%) compared to controls (n = 14, 1% ± 0–6%). This was particularly evident in moderate to severe optic disc swelling (n = 23, 10% ± 0–58%, p < 0.001). RNFL thickness was unable to be quantified using SDOCT in patients with severe papilloedema.ConclusionsSegE remain a concern for clinicians using SDOCT to monitor papilloedema in IIH, particularly in the assessment of eyes with moderate to severe oedema. Systematic assessment and manual refinement of SegE is therefore important to ensure the accuracy in longitudinal monitoring of patients.

【 授权许可】

CC BY   
© The Author(s). 2018