Cardiovascular RiskprofilE - IMaging and gender-specific disOrders (CREw-IMAGO): rationale and design of a multicenter cohort study

BMC Women's Health

Study Protocol

Eric Boersma¹  Jolien W. Roos-Hesselink¹  Angela H.E.M. Maas²  Jeanine E. Roeters van Lennep³  Eric A.P. Steegers⁴  Laura Benschop⁴  Christianne J.M. de Groot⁵  Ricardo P.J. Budde⁶  Aad van der Lugt⁶  Birgitta K. Velthuis⁷  Bart C.J.M. Fauser⁸  Cindy Meun⁹  Joop S.E. Laven⁹  Karl G.M. Moons^1,10  Arie Franx^1,11  Gerbrand A. Zoet^1,11  Bas B. van Rijn^1,12 

[1] Department of Cardiology, Erasmus Medical Center, ‘s-Gravendijkwal 230, 3015CE, Rotterdam, The Netherlands;Department of Cardiology, Radboud University Medical Center, Geert Grooteplein-Zuid 10, 6525, Nijmegen, GA, The Netherlands;Department of Internal Medicine, Erasmus Medical Center, ‘s-Gravendijkwal 230, 3015CE, Rotterdam, The Netherlands;Department of Obstetrics & Gynaecology, University Medical Center Rotterdam, Erasmus MC, ‘s-Gravendijkwal 230, 3015CE, Rotterdam, The Netherlands;Department of Obstetrics and Gynecology, VU University Medical Center, De Boelelaan 1117, 1081, Amsterdam, HV, The Netherlands;Department of Radiology, Erasmus Medical Center, ‘s-Gravendijkwal 230, 3015CE, Rotterdam, The Netherlands;Department of Radiology, University Medical Center Utrecht, Heidelberglaan 100, 3584, Utrecht, CX, The Netherlands;Department of Reproductive Medicine & Gynaecology, University Medical Center Utrecht, Heidelberglaan 100, 3584, Utrecht, CX, The Netherlands;Division of Reproductive Medicine, Department of Obstetrics and Gynaecology, Erasmus Medical Center, ‘s-Gravendijkwal 230, 3015CE, Rotterdam, The Netherlands;Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heidelberglaan 100, 3584, Utrecht, CX, The Netherlands;Wilhelmina Children’s Hospital Birth Center, University Medical Center Utrecht, Lundlaan 6, 3508, Utrecht, AB, The Netherlands;Wilhelmina Children’s Hospital Birth Center, University Medical Center Utrecht, Lundlaan 6, 3508, Utrecht, AB, The Netherlands;Academic Unit of Human Development and Health, University of Southampton, Princess Anne Hospital, Coxford Road, SO16 5YA, Southampton, UK;

关键词: Reproductive disorders;    Hypertensive pregnancy disorders;    Polycystic ovarian syndrome;    Primary ovarian insufficiency;    Cardiovascular risk factors;    Cardiovascular disease;    CT angiography;    Coronary artery calcium;    Carotid siphon calcification;    Cell-based biomarkers;   

DOI  :  10.1186/s12905-017-0415-x

 received in 2017-02-12, accepted in 2017-08-01,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundReproductive disorders, such as polycystic ovary syndrome (PCOS), primary ovarian insufficiency (POI) and hypertensive pregnancy disorders (HPD) like pre-eclampsia (PE), are associated with an increased risk of cardiovascular disease (CVD). Detection of early signs of cardiovascular disease (CVD), as well as identification of risk factors among women of reproductive age which improve cardiovascular risk prediction, is a challenge and current models might underestimate long-term health risks. The aim of this study is to assess cardiovascular disease in patients with a history of a reproductive disorder by low-dose computed tomography (CT).MethodsWomen of 45 - 55 years, who experienced a reproductive disorder (PCOS, POI, HPD), are invited to participate in this multicenter, prospective, cohort study. Women will be recruited after regular cardiovascular screening, including assessment of classical cardiovascular risk factors. CT of the coronary arteries (both coronary artery calcium scoring (CACS), and contrast-enhanced coronary CT angiography (CCTA)) and carotid siphon calcium scoring (CSC) is planned in 300 women with HPD and 300 women with PCOS or POI. In addition, arterial stiffness (non-invasive pulse wave velocity (PWV)) measurement and cell-based biomarkers (inflammatory circulating cells) will be obtained.DiscussionInitial inclusion is focused on women of 45 - 55 years. However, the age range (40 - 45 years and/or ≥ 55 years) and group composition may be adjusted based on the findings of the interim analysis. Participants can potentially benefit from information obtained in this study concerning their current cardiovascular health and expected future risk of cardiovascular events. The results of this study will provide insights in the development of CVD in women with a history of reproductive disorders. Ultimately, this study may lead to improved cardiovascular prediction models and will provide an opportunity for timely adjustment of preventive strategies. Limitations of this study include the possibility of overdiagnosis and the average radiation dose of 3.5 mSv during coronary and carotid siphon CT, although the increased lifetime malignancy risk is negligible.Trial registrationNetherlands Trial Register, NTR5531. Date registered: October 21st, 2015.

【 授权许可】

CC BY   
© The Author(s). 2017