Adeno-associated virus infection and its impact in human health: an overview

Virology Journal

卷:19

Review

Natalia M Araujo¹  Thaís B Sant’Anna¹ 

[1] Laboratory of Molecular Virology, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil;

关键词: Adeno-associated virus;    Pathogenesis;    Tumorigenesis;    Hepatocellular carcinoma;    Cervical cancer;    Reproductive disorders;    Wildtype AAV;    Gene therapy;    Human health;   

DOI  :  10.1186/s12985-022-01900-4

 received in 2022-08-09, accepted in 2022-10-10,  发布年份 2022

来源: Springer

【 摘 要 】

Discovered as a contaminant of adenovirus stocks in the 1960s, adeno-associated virus (AAV) is a mono-stranded DNA virus that depends on helper factors to replicate. Even though AAV is endemic in the human population (35–80%), it is remarkable that many issues concerning the natural infection by this virus remain unanswered. In this study, we reflect on the main basic aspects of AAV biology and provide an overview of the studies exploring the impact of AAV infection on human health, focusing on three major research areas including, (i) cervical and (ii) liver cancer, and (iii) reproductive system disorders. Conflicting results have been obtained into the association of AAV infection with the occurrence of adverse reproductive outcomes, such as placental complications, spontaneous abortion, and fertility disorders, or with a protective role in HPV-related cervical carcinogenesis. Noteworthy, recent reports have identified AAV insertional mutagenesis as a novel risk factor for the development of hepatocellular carcinoma. This latest finding raises concern regarding the widespread usage of AAV vectors in liver-targeted gene therapy.

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

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