Measles vaccine coverage estimates in an outbreak three years after the nation-wide campaign in China: implications for measles elimination, 2013

BMC Infectious Diseases

Research Article

Yanhua Yang¹  Lidong Gao¹  Fangjun Li¹  Junhua Li¹  Hong Zhang¹  Bosong Guo²  Chao Ma³  Mengjuan Duan³  Li Li³  Qiru Su³  Huiming Luo³  Lixin Hao³  Huaqing Wang³  Shanliang Xiao⁴  Xiang Zheng⁵  Lance Rodewald⁶ 

[1]Hunan Province Center for Disease Control and Prevention, Changsha, Hu Nan province, China

[2]Longhui County Center for Disease Control and Prevention, Shaoyang, Hu Nan province, China

[3]National Immunization Programme, Chinese Center for Disease Control and Prevention, 27 Nanwei Road, Xicheng District, Beijing, China

[4]Shaoyang Prefecture Center for Disease Control and Prevention, Shaoyang, Hu Nan province, China

[5]Taizhou Prefecture Center for Disease Control and Prevention, Taizhou, Zhe Jiang province, China

[6]World Health Organization Office in China, Beijing, China

关键词: Measles;    Vaccination;    Coverage;    Estimation;    Elimination;    China;   

DOI  :  10.1186/s12879-015-0752-z

 received in 2014-10-27, accepted in 2015-01-12,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundChina is approaching measles elimination, but indigenous measles still circulates. County L in China has reported measles-containing vaccine (MCV) coverage rates >95% since 2000. Despite high reported coverage, a large measles outbreak occurred among young children in L County. We measured MCV coverage using 5 different methods during an investigation on this outbreak and compared our estimates with reported rates.MethodsReported coverage rates are determined by aggregating clinic-based data across the county: doses administered in each clinic divided by the number of children registered in each clinic. Our methods estimated coverage for the 2010–2012 birth cohort, and were (1) administrative method: doses administered in clinics divided by the birth cohort recorded in the Statistical Year Book, (2) house-to-house convenience-sample survey of children living near cases, (3) vaccination clinic records review, (4) determination of a convenience sample of measles outbreak cases’ vaccination statuses and using the field vaccine efficacy outbreak equation to estimate population coverage, and (5) a seroprevalence survey using a convenience sample of residual blood samples from hospitals.ResultsThe measles outbreak totaled 215 cases, representing an incidence of 195.8 per million population. Our estimated MCV coverage rates were: (1) administrative method: 84.1%-87.0% for MCV1 and 80.3%-90.0% for MCV2, (2) in-house survey: 83.3% of 9–17 month children received MCV1, and 74.5% of 24–47 month children received MCV2, (3) clinic record review: 85.5% of 9–17 month children received MCV1, and 73.2% of 24–59 month children received MCV2, (4) field VE method: 83.6% of 9–47 month children received one or more MCV doses, and (5) serology: seropositive rates were <80% in the 12–17 and 18–23 month age cohorts.ConclusionsCompared with reported coverage >95%, our 5 coverage assessments all showed substantially lower coverage. China should evaluate guidelines for reporting vaccination coverage and identify feasible improvements to the assessment methods.

【 授权许可】

Unknown   
© Ma et al.; licensee BioMed Central. 2015. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.