Effectiveness of EMDR in patients with substance use disorder and comorbid PTSD: study protocol for a randomized controlled trial

BMC Psychiatry

Study Protocol

Günter Mainusch¹  Laycen Chuey-Ferrer¹  Annett Lotzin²  Ingo Schäfer²  Arne Hofmann³  Peter Lieberman³ 

[1] AHG Clinic Dormagen, Dormagen, Germany;Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;Center for Interdisciplinary Addiction Research, Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, University of Hamburg, Martinistr. 52, D-20246, Hamburg, Germany;EMDR-Institute Germany, Bergisch Gladbach, Germany;

关键词: Posttraumatic stress disorder;    Alcohol;    Substance abuse;    Addiction;    Comorbidity;    Eye movement desensitization and reprocessing;    Trauma-focused treatment;    Exposure-based treatment;    Psychotherapy outcome research;   

DOI  :  10.1186/s12888-017-1255-9

 received in 2017-02-08, accepted in 2017-03-04,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundEye Movement Desensitization and Reprocessing (EMDR) is an evidence-based treatment for PTSD. However, it is unclear whether EMDR shows the same effectiveness in patients with substance use disorders (SUD) and comorbid PTSD. In this trial, we examine the effectiveness of EMDR in reducing PTSD symptoms in patients with SUD and PTSD.Methods/DesignWe conduct a single-blinded RCT among 158 patients with SUD and comorbid PTSD admitted to a German addiction rehabilitation center specialized for the treatment of patients with SUD and comorbid PTSD. Patients are randomized to receive either EMDR, added to SUD rehabilitation and non-trauma-focused PTSD treatment (TAU), or TAU alone. The primary outcome is change from baseline in PTSD symptom severity as measured by the Clinician-Administered PTSD Scale at 6-month follow-up. Secondary outcomes are change from baseline in substance use, addiction-related problems, depressive symptoms, dissociative symptoms, emotion dysregulation and quality of life. Assessments are carried out by blinded raters at admission, at end of treatment, and at 3- and 6-month follow-up. We expect that EMDR plus TAU will be more effective in reducing PTSD symptoms than TAU alone. Mixed models will be conducted using an intention-to-treat and per-protocol approach.DiscussionThis study aims to expand the knowledge about the effectiveness of EMDR in patients with SUD and comorbid PTSD. The expected finding of the superiority of EMDR in reducing PTSD symptoms compared to non-trauma-focused PTSD treatment may enhance the use of trauma-focused treatment approaches for patients with SUD and co-morbid PTSD.Trial registrationGerman Clinical Trials Register: DRKS00009007; U1111-1172-9213. Retrospectively registered 01 Juni 2016.

【 授权许可】

CC BY   
© The Author(s). 2017