Bilateral cystoid macular edema following docetaxel chemotherapy in a patient with retinitis pigmentosa: a case report

BMC Ophthalmology

Case Report

Kinga Kammerer¹  Anna Enzsoly²  Miklos Schneider²  Janos Nemeth² 

[1] Department of Oncology, Flor Ferenc Hospital of Pest County, Kistarcsa, Hungary;Department of Ophthalmology, Semmelweis University, Faculty of Medicine, H-1085 Maria u. 39, Budapest, Hungary;

关键词: Docetaxel;    Cystoid macular edema;    Optical coherence tomography;    Retinitis pigmentosa;   

DOI  :  10.1186/s12886-015-0020-4

 received in 2014-10-29, accepted in 2015-03-19,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundDocetaxel is a chemotherapeutic agent of the taxane class of drugs for the treatment of breast cancer. We present a female patient who noted decreased vision after docetaxel treatment.Case presentationA 45-year-old female patient received docetaxel treatment after resection of a breast carcinoma. Funduscopy and optical coherence tomography (OCT) showed cystoid macular edema on both eyes. Dilated funduscopy also showed bone spicule-like pigmented deposits, typical for retinitis pigmentosa. Besides the fundus appearance restricted peripheral vision and scotopic electroretinogram confirmed the diagnosis of retinitis pigmentosa. Chemotherapy was discontinued following a consulation with the oncologist of the patient. After five weeks, visual acuity improved significantly along with decrease of retinal thickness measured by OCT.ConclusionDocetaxel may cause ocular adverse effects such as cystoid macular edema. Ophthalmological examination is warranted for patients with visual complaints during docetaxel chemotherapy.

【 授权许可】

Unknown   
© Enzsoly et al.; licensee BioMed Central. 2015. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.