Induced Higher-order aberrations after Laser In Situ Keratomileusis (LASIK) Performed with Wavefront-Guided IntraLase Femtosecond Laser in moderate to high Astigmatism

BMC Ophthalmology

Research Article

Ferial M. Al-Zeraid¹  Uchechukwu L. Osuagwu² 

[1] Department of Optometry & Vision Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, P.O Box 10219, 11433, Riyadh, Saudi Arabia;Department of Optometry & Vision Sciences, Faculty of Health, Ophthalmic and Visual Optics Laboratory Group (Chronic Disease & Ageing), Institute of Health and Biomedical Innovation, Q Block, Room 5WS36 60 Musk Avenue Kelvin Grove, 4059, Brisbane, QLD, Australia;

关键词: Laser-assisted in situ keratomileusis;    Wavefront-guided;    Myopia;    Astigmatism;    Intralase;    Femtosecond laser;    Distance visual acuity;    Coma;    Spherical aberration;    Higher-order aberration;   

DOI  :  10.1186/s12886-016-0205-5

 received in 2015-06-18, accepted in 2016-03-07,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundWavefront-guided Laser-assisted in situ keratomileusis (LASIK) is a widespread and effective surgical treatment for myopia and astigmatic correction but whether it induces higher-order aberrations remains controversial. The study was designed to evaluate the changes in higher-order aberrations after wavefront-guided ablation with IntraLase femtosecond laser in moderate to high astigmatism.MethodsTwenty-three eyes of 15 patients with moderate to high astigmatism (mean cylinder, −3.22 ± 0.59 dioptres) aged between 19 and 35 years (mean age, 25.6 ± 4.9 years) were included in this prospective study. Subjects with cylinder ≥ 1.5 and ≤2.75 D were classified as moderate astigmatism while high astigmatism was ≥3.00 D. All patients underwent a femtosecond laser–enabled (150-kHz IntraLase iFS; Abbott Medical Optics Inc) wavefront-guided ablation. Uncorrected (UDVA), corrected (CDVA) distance visual acuity in logMAR, keratometry, central corneal thickness (CCT) and higher-order aberrations (HOAs) over a 6 mm pupil, were assessed before and 6 months, postoperatively. The relationship between postoperative change in HOA and preoperative mean spherical equivalent refraction, mean astigmatism, and postoperative CCT were tested.ResultsAt the last follow-up, the mean UDVA was increased (P < 0.0001) but CDVA remained unchanged (P = 0.48) and no eyes lost ≥2 lines of CDVA. Mean spherical equivalent refraction was reduced (P < 0.0001) and was within ±0.50 D range in 61 % of eyes. The average corneal curvature was flatter by 4 D and CCT was reduced by 83 μm (P < 0.0001, for all), postoperatively. Coma aberrations remained unchanged (P = 0.07) while the change in trefoil (P = 0.047) postoperatively, was not clinically significant. The 4th order HOAs (spherical aberration and secondary astigmatism) and the HOA root mean square (RMS) increased from −0.18 ± 0.07 μm, 0.04 ± 0.03 μm and 0.47 ± 0.11 μm, preoperatively, to 0.33 ± 0.19 μm (P = 0.004), 0.21 ± 0.09 μm (P < 0.0001) and 0.77 ± 0.27 μm (P < 0.0001), six months postoperatively. The change in spherical aberration after the procedure increased with an increase in the degree of preoperative myopia.ConclusionsWavefront-guided IntraLASIK offers a safe and effective option for vision and visual function improvement in astigmatism. Although, reduction of HOA is possible in a few eyes, spherical-like aberrations are increased in majority of the treated eyes.

【 授权许可】

CC BY   
© Al-Zeraid and Osuagwu. 2016