Mutagenicity and antimutagenicity of six Brazilian Byrsonima species assessed by the Ames test

BMC Complementary and Alternative Medicine

Research Article

Wagner Vilegas¹  Lívia Greghi Espanha²  Flávia Aparecida Resende²  Catarine Haidê Nogueira²  Paula Karina Boldrin²  Mariana Santoro de Camargo²  Eliana Aparecida Varanda²  Rone Aparecido De Grandis²  José de Sousa Lima Neto³  Lourdes Campaner dos Santos³ 

[1] Campus do Litoral Paulista - Unidade São Vicente, UNESP-São Paulo State University, 11330-900, São Vicente, São Paulo, Brazil;Department of Biological Sciences, Faculty of Pharmaceutical Sciences of Araraquara, UNESP- São Paulo State University, Rodovia Araraquara-Jaú, km 1, 14801-902, Araraquara, São Paulo, Brazil;Department of Organic Chemistry, Chemistry Institute of Araraquara, UNESP- São Paulo State University, Rua Francisco Degni s/n, Bairro Quitandinha, c.p. 355, 14800-900, Araraquara, São Paulo, Brazil;

关键词: Salmonella;    Chemoprevention;    Medicinal plants;   

DOI  :  10.1186/1472-6882-14-182

 received in 2013-12-16, accepted in 2014-05-29,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundIn various regions of Brazil, several species of the genus Byrsonima (Malpighiaceae) are widely used to treat gastrointestinal complications. This genus has about 150 species of shrubs and trees distributed over the entire Neotropical region. Various biological activities have been identified in these plants, especially antioxidant, antimicrobial and topical and systemic anti-inflammatory activities. The aim of this study was to investigate the mutagenicity and antimutagenicity of hydroalcoholic leaf extracts of six species of Byrsonima: B. verbascifolia, B. correifolia, B. coccolobifolia, B. ligustrifolia, B. fagifolia and B. intermedia by the Salmonella microsome assay (Ames test).MethodsMutagenic and antimutagenic activity was assessed by the Ames test, with the Salmonella typhimurium tester strains TA100, TA98, TA97a and TA102, with (+S9) and without (-S9) metabolization, by the preincubation method.ResultsOnly B. coccolobifolia and B. ligustrifolia showed mutagenic activity. However, the extracts of B. verbascifolia, B. correifolia, B. fagifolia and B. intermedia were found to be strongly antimutagenic against at least one of the mutagens tested.ConclusionsThese results contribute to valuable data on the safe use of medicinal plants and their potential chemopreventive effects. Considering the excellent antimutagenic activities extracted from B. verbascifolia, B. correifolia, B. fagifolia and B. intermedia, these extracts are good candidate sources of chemopreventive agents. However, B. coccolobifolia and B. ligustrifolia showed mutagenic activity, suggesting caution in their use.

【 授权许可】

Unknown   
© Espanha et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.