Mutagenicity and antimutagenicity of six Brazilian Byrsonima species assessed by the Ames test

BMC Complementary and Alternative Medicine

Eliana Aparecida Varanda³  Wagner Vilegas²  Lourdes Campaner dos Santos¹  Rone Aparecido De Grandis³  Mariana Santoro de Camargo³  Catarine Haidê Nogueira³  Paula Karina Boldrin³  José de Sousa Lima Neto¹  Flávia Aparecida Resende³  Lívia Greghi Espanha³ 

[1] Department of Organic Chemistry, Chemistry Institute of Araraquara, UNESP- São Paulo State University, Rua Francisco Degni s/n, Bairro Quitandinha, c.p. 355, 14800-900 Araraquara, São Paulo, Brazil;Campus do Litoral Paulista - Unidade São Vicente, UNESP-São Paulo State University, 11330-900 São Vicente, São Paulo, Brazil;Department of Biological Sciences, Faculty of Pharmaceutical Sciences of Araraquara, UNESP- São Paulo State University, Rodovia Araraquara-Jaú, km 1, 14801-902 Araraquara, São Paulo, Brazil

关键词: Medicinal plants;    Chemoprevention;    Salmonella/microsome assay;   

Others  :  1220111
DOI  :  10.1186/1472-6882-14-182

 received in 2013-12-16, accepted in 2014-05-29,  发布年份 2014

【 摘 要 】

Background

In various regions of Brazil, several species of the genus Byrsonima (Malpighiaceae) are widely used to treat gastrointestinal complications. This genus has about 150 species of shrubs and trees distributed over the entire Neotropical region. Various biological activities have been identified in these plants, especially antioxidant, antimicrobial and topical and systemic anti-inflammatory activities. The aim of this study was to investigate the mutagenicity and antimutagenicity of hydroalcoholic leaf extracts of six species of Byrsonima: B. verbascifolia, B. correifolia, B. coccolobifolia, B. ligustrifolia,B. fagifolia and B. intermedia by the Salmonella microsome assay (Ames test).

Methods

Mutagenic and antimutagenic activity was assessed by the Ames test, with the Salmonella typhimurium tester strains TA100, TA98, TA97a and TA102, with (+S9) and without (-S9) metabolization, by the preincubation method.

Results

Only B. coccolobifolia and B. ligustrifolia showed mutagenic activity. However, the extracts of B. verbascifolia, B. correifolia, B. fagifolia and B. intermedia were found to be strongly antimutagenic against at least one of the mutagens tested.

Conclusions

These results contribute to valuable data on the safe use of medicinal plants and their potential chemopreventive effects. Considering the excellent antimutagenic activities extracted from B. verbascifolia, B. correifolia, B. fagifolia and B. intermedia, these extracts are good candidate sources of chemopreventive agents. However, B. coccolobifolia and B. ligustrifolia showed mutagenic activity, suggesting caution in their use.

【 授权许可】

   
2014 Espanha et al.; licensee BioMed Central Ltd.

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