Multimodal MRI for early diabetic mild cognitive impairment: study protocol of a prospective diagnostic trial

BMC Medical Imaging

Study Protocol

Guang-Bin Cui¹  Hai-Yan Nan¹  Ying Yu¹  Qian Sun¹  Lin-Feng Yan¹  Yu-Chuan Hu¹  Zhi-Cheng Liu¹  Yang Yang¹  Wen Wang¹ 

[1] Department of Radiology, Tangdu Hospital, Fourth Military Medical University, 569 Xinsi Road, 710038, Xi’an, China;

关键词: Type 2 diabetes mellitus;    Mild cognitive impairment;    Neuroimaging techniques;    Prodromal diabetic stage;    Microstructural alterations;    Microvascular alterations;   

DOI  :  10.1186/s12880-016-0152-x

 received in 2015-12-02, accepted in 2016-08-07,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundType 2 diabetes mellitus (T2DM) is a risk factor for dementia. Mild cognitive impairment (MCI), an intermediary state between normal cognition and dementia, often occurs during the prodromal diabetic stage, making early diagnosis and intervention of MCI very important. Latest neuroimaging techniques revealed some underlying microstructure alterations for diabetic MCI, from certain aspects. But there still lacks an integrated multimodal MRI system to detect early neuroimaging changes in diabetic MCI patients. Thus, we intended to conduct a diagnostic trial using multimodal MRI techniques to detect early diabetic MCI that is determined by the Montreal Cognitive Assessment (MoCA).MethodsIn this study, healthy controls, prodromal diabetes and diabetes subjects (53 subjects/group) aged 40-60 years will be recruited from the physical examination center of Tangdu Hospital. The neuroimaging and psychometric measurements will be repeated at a 0.5 year-interval for 2.5 years’ follow-up. The primary outcome measures are 1) Microstructural and functional alterations revealed with multimodal MRI scans including structure magnetic resonance imaging (sMRI), resting state functional magnetic resonance imaging (rs-fMRI), diffusion kurtosis imaging (DKI), and three-dimensional pseudo-continuous arterial spin labeling (3D-pCASL); 2) Cognition evaluation with MoCA. The second outcome measures are obesity, metabolic characteristics, lifestyle and quality of life.DiscussionThe study will provide evidence for the potential use of multimodal MRI techniques with psychometric evaluation in diagnosing MCI at prodromal diabetic stage so as to help decision making in early intervention and improve the prognosis of T2DM.Trial registrationThis study has been registered to ClinicalTrials.gov (NCT02420470) on April 2, 2015 and published on July 29, 2015.

【 授权许可】

CC BY   
© The Author(s). 2016