Inverted U-shaped correlation between serum low-density lipoprotein cholesterol levels and cognitive functions of patients with type 2 diabetes mellitus

Lipids in Health and Disease

Tong Niu¹  Ke An¹  Shaohua Wang¹  Jijing Shi¹  Wenwen Zhu¹  Zheng Wang¹  Haoqiang Zhang¹  Wuyou Cao¹ 

[1] Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University, No.87 Dingjiaqiao Road, 210009, Nanjing, PR China;School of Medicine, Southeast University, 210009, Nanjing, PR China;

关键词: Cholesterol;    Low-density lipoprotein cholesterol;    Lipids disorder;    Type 2 diabetes mellitus;    Cognitive function;    Mild cognitive impairment;   

DOI  :  10.1186/s12944-021-01534-5

来源: Springer

【 摘 要 】

BackgroundLow-density lipoprotein cholesterol (LDL-C) metabolic disorder is common in individuals with diabetes. The role of LDL-C in mild cognitive impairment (MCI) remains to be explored. We aim to investigate the associations between LDL-C at different levels and details of cognition decline in patients with type 2 diabetes mellitus (T2DM).MethodsPatients with T2DM (n = 497) were recruited. Clinical parameters and neuropsychological tests were compared between patients with MCI and controls. Goodness of fit was assessed to determine the linear or U-shaped relationship between LDL-C and cognitive function. The cut-off point of LDL-C was calculated. Correlation and regression were carried out to explore the relationship between cognitive dysfunction and LDL-C levels above and below the cut-off point.ResultsAlthough no significant difference in LDL-C levels was detected in 235 patients with MCI, compared with 262 patients without MCI, inverted-U-shaped association was determined between LDL-C and Montreal Cognitive Assessment (MoCA). The cut-off point of LDL-C is 2.686 mmol/l. LDL-C (>2.686 mmol/l) is positively related to Trail Making Test B (TMTB) indicating executive function. LDL-C (<2.686 mmol/l) is positively associated with Clock Drawing Test (CDT) reflecting visual space function in patients with T2DM.ConclusionInverted U-shaped correlation was found between serum LDL-C and cognitive function in patients with T2DM. Despite that the mechanisms of different LDL-C levels involved in special cognitive dysfunctions remain incompletely clarified, excessive LDL-C damages executive function, while the deficient LDL-C impairs visual space function.Trial registrationChiCTR-OCC-15006060.

【 授权许可】

CC BY