The role of vitamin D in pre-eclampsia: a systematic review

BMC Pregnancy and Childbirth

Research Article

Heather M. Larkin¹  Juhi M. Purswani¹  Saurabh Mehta²  Pratibha Dwarkanath³  Anura Kurpad³  Pooja Gala⁴ 

[1] Division of Nutritional Sciences, Cornell University, 314 Savage Hall, 14853, Ithaca, NY, USA;Division of Nutritional Sciences, Cornell University, 314 Savage Hall, 14853, Ithaca, NY, USA;St. John’s Research Institute, Bangalore, Karnataka, India;St. John’s Research Institute, Bangalore, Karnataka, India;Weill-Cornell Medical College, New York, NY, USA;

关键词: Vitamin D;    Pregnancy;    Pregnancy-induced hypertension;    Pre-eclampsia;    Endothelial function;   

DOI  :  10.1186/s12884-017-1408-3

 received in 2015-09-18, accepted in 2017-07-03,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundThe etiology of pre-eclampsia (PE) is not yet fully understood, though current literature indicates an upregulation of inflammatory mediators produced by the placenta as a potential causal mechanism. Vitamin D is known to have anti-inflammatory properties and there is evidence of an inverse relationship between dietary calcium intake and the incidence of PE. Evidence of the role of vitamin D status and supplementation in the etiology and prevention of PE is reviewed in this article along with identification of research gaps to inform future studies.MethodsWe conducted a structured literature search using MEDLINE electronic databases to identify published studies until February 2015. These sources were retrieved, collected, indexed, and assessed for availability of pregnancy-related data on PE and vitamin D.ResultsSeveral case-control studies and cross-sectional studies have shown an association between vitamin D status and PE, although evidence has been inconsistent. Clinical trials to date have been unable to show an independent effect of vitamin D supplementation in preventing PE.ConclusionsThe included clinical trials do not show an independent effect of vitamin D supplementation in preventing PE; however, issues with dose, timing, and duration of supplementation have not been completely addressed.

【 授权许可】

CC BY   
© The Author(s). 2017