Intensive expression of Bmi-1 is a new independent predictor of poor outcome in patients with ovarian carcinoma

BMC Cancer

Research Article

Wei-Peng He¹  Jun-Hang Luo¹  Xin-Yuan Guan²  Dan Xie²  Mu-Yan Cai²  Mu-Sheng Zeng²  Li-Ru He²  Hai-Xia Deng²  Yi-Xin Zeng²  Guo-Fen Yang³ 

[1] Department of Gynecology, the First Affiliated Hospital, Sun Yat-Sen University, No. 78, Zhongshan Road II, 510080, Guangzhou, China;State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, No. 651, Dongfeng Road East, 510060, Guangzhou, China;State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, No. 651, Dongfeng Road East, 510060, Guangzhou, China;Department of Gynecology, the First Affiliated Hospital, Sun Yat-Sen University, No. 78, Zhongshan Road II, 510080, Guangzhou, China;

关键词: Ovarian Carcinoma;    Figo Stage;    Borderline Tumor;    Normal Ovary;    Univariate Survival Analysis;   

DOI  :  10.1186/1471-2407-10-133

 received in 2009-10-12, accepted in 2010-04-08,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundIt has been suggested that the B-cell specific moloney leukemia virus insertion site 1 (Bmi-1) gene plays an oncogenic role in several types of human cancer, but the status of Bmi-1 amplification and expression in ovarian cancer and its clinical/prognostic significance are unclear.MethodsThe methods of immunohistochemistry and fluorescence in situ hybridization were utilized to examine protein expression and amplification of Bmi-1 in 30 normal ovaries, 30 ovarian cystadenomas, 40 borderline ovarian tumors and 179 ovarian carcinomas.ResultsIntensive expression of Bmi-1 was detected in none of the normal ovaries, 3% cystadenomas, 10% borderline tumors, and 37% ovarian carcinomas, respectively. Amplification of Bmi-1 was detected in 8% of ovarian carcinomas. In ovarian carcinomas, significant positive associations were found between intensive expression of Bmi-1 and the tumors ascending histological grade, later pT/pN/pM and FIGO stages (P < 0.05). In univariate survival analysis of the ovarian carcinoma cohorts, a significant association of intensive expression of Bmi-1 with shortened patient survival (mean 49.3 months versus 100.3 months, p < 0.001) was demonstrated. Importantly, Bmi-1 expression provided significant independent prognostic parameters in multivariate analysis (p = 0.005).ConclusionsThese findings provide evidence that intensive expression of Bmi-1 might be important in the acquisition of an invasive and/or aggressive phenotype of ovarian carcinoma, and serve as a independent biomarker for shortened survival time of patients.

【 授权许可】

Unknown   
© Yang et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.