Recent alcohol consumption and risk of incident ovarian carcinoma: a pooled analysis of 5,342 cases and 10,358 controls from the Ovarian Cancer Association Consortium

BMC Cancer

Research Article

Pamela J Thompson¹  Michael E Carney¹  Galina Lurie¹  Marc T Goodman²  Allan Jensen³  Estrid Høgdall³  Susanne Krüger Kjær⁴  Jolanta Lissowska⁵  Harvey A Risch⁶  Joellen M Schildkraut⁷  Martin Köbel⁸  Linda E Kelemen⁹  Hannah Yang^1,10  Louise A Brinton^1,10  Jenny Chang-Claude^1,11  Montserrat Garcia-Closas^1,12  Mary Anne Rossing^1,13  Jennifer A Doherty^1,13  Robert Edwards^1,14  Sara H Olson^1,15  Allison F Vitonis^1,16  Daniel W Cramer^1,17  Kathryn L Terry^1,17  Kirsten Moysich^1,18  Urmila Chandran^1,19  Elisa V Bandera^1,19  Melony King^1,19  Penelope M Webb^2,20  Clare Bunker^2,21  Roberta B Ness^2,22 

[1] Cancer Research Center, University of Hawaii, Honolulu, HI, USA;Cancer Research Center, University of Hawaii, Honolulu, HI, USA;Departments of Medicine and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA;Danish Cancer Society Research Center, Copenhagen, Denmark;Danish Cancer Society Research Center, Copenhagen, Denmark;Gynecologic Clinic, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark;Department of Cancer Epidemiology and Prevention, The M. Sklodowska-Curie Cancer Center and Institute of Oncology, Gliwice, Poland;Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA;Department of Community and Family Medicine and the Comprehensive Cancer Center, Duke University Medical Center, Durham, NC, USA;Department of Pathology and Laboratory Medicine, Calgary Laboratory Services, Calgary, AB, Canada;Department of Population Health Research, Alberta Health Services-Cancer Care and Departments of Medical Genetics and Oncology, University of Calgary, Calgary, AB, Canada;Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA;Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany;Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, United Kingdom;Fred Hutchinson Cancer Research Center, Seattle, WA, USA;Magee Womens Research Institute, Pittsburgh, PA, USA;Memorial Sloan-Kettering Cancer Center, New York, NY, USA;Obstetrics and Gynecology Epidemiology Center, Brigham and Women’s Hospital, Boston, MA, USA;Obstetrics and Gynecology Epidemiology Center, Brigham and Women’s Hospital, Boston, MA, USA;Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA;Roswell Park Cancer Center, Buffalo, NY, USA;The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ, USA;The Queensland Institute of Medical Research, Locked Bag 2000 Royal Brisbane Hospital, Herston, Australia;University of Pittsburgh School of Public Health, Pittsburgh, PA, USA;University of Texas School of Public Health, Houston, TX, USA;

关键词: Alcohol Intake;    Ovarian Carcinoma;    Borderline Tumor;    Total Alcohol;    Clear Cell Ovarian Carcinoma;   

DOI  :  10.1186/1471-2407-13-28

 received in 2012-08-01, accepted in 2013-01-17,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundStudies evaluating the association between alcohol intake and ovarian carcinoma (OC) are inconsistent. Because OC and ovarian borderline tumor histologic types differ genetically, molecularly and clinically, large numbers are needed to estimate risk associations.MethodsWe pooled data from 12 case-control studies in the Ovarian Cancer Association Consortium comprising 5,342 OC cases, 1,455 borderline tumors and 10,358 controls with quantitative information on recent alcohol intake to estimate odds ratios (OR) and 95% confidence intervals (CI) according to frequencies of average daily intakes of beer, wine, liquor and total alcohol.ResultsTotal alcohol intake was not associated with all OC: consumption of >3 drinks per day compared to none, OR=0.92, 95% CI=0.76-1.10, P trend=0.27. Among beverage types, a statistically non-significant decreased risk was observed among women who consumed >8 oz/d of wine compared to none (OR=0.83, 95% CI=0.68-1.01, P trend=0.08). This association was more apparent among women with clear cell OC (OR, 0.43; 95% CI, 0.22-0.83; P trend=0.02), although based on only 10 cases and not statistically different from the other histologic types (P value for statistical heterogeneity between histologic types = 0.09). Statistical heterogeneity of the alcohol- and wine-OC associations was seen among three European studies, but not among eight North American studies. No statistically significant associations were observed in separate analyses evaluating risk with borderline tumors of serous or mucinous histology. Smoking status did not significantly modify any of the associations.ConclusionsWe found no evidence that recent moderate alcohol drinking is associated with increased risk for overall OC, or that variation in risk is associated strongly with specific histologic types. Understanding modifiable causes of these elusive and deadly cancers remains a priority for the research community.

【 授权许可】

CC BY   
© Kelemen et al.; licensee BioMed Central Ltd. 2013