Treatment-seeking patients with binge-eating disorder in the Swedish national registers: clinical course and psychiatric comorbidity

BMC Psychiatry

Research Article

Henrik Larsson¹  Andreas Jangmo¹  Elisabeth Welch¹  Cynthia M. Bulik²  Laura M. Thornton³  Manjiri Pawaskar⁴  Barry K. Herman⁴  Yvonne von Hausswolff-Juhlin⁵  Claes Norring⁵ 

[1] Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden;Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden;Department of Psychiatry, University of North Carolina at Chapel Hill, CB #7160, 101 Manning Drive, 27599-7160, Chapel Hill, NC, USA;Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA;Department of Psychiatry, University of North Carolina at Chapel Hill, CB #7160, 101 Manning Drive, 27599-7160, Chapel Hill, NC, USA;Shire, Wayne, PA, USA;Stockholm Centre for Eating Disorders, Stockholm, Sweden;Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden;

关键词: Binge-eating disorder;    Comorbidity;    Suicide;    Eating disorders;   

DOI  :  10.1186/s12888-016-0840-7

 received in 2015-08-31, accepted in 2016-05-02,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundWe linked extensive longitudinal data from the Swedish national eating disorders quality registers and patient registers to explore clinical characteristics at diagnosis, diagnostic flux, psychiatric comorbidity, and suicide attempts in 850 individuals diagnosed with binge-eating disorder (BED).MethodCases were all individuals who met criteria for BED in the quality registers (N = 850). We identified 10 controls for each identified case from the Multi-Generation Register matched on sex, and year, month, and county of birth. We evaluated characteristics of individuals with BED at evaluation and explored diagnostic flux across eating disorders presentations between evaluation and one-year follow-up. We applied conditional logistic regression models to assess the association of BED with each comorbid psychiatric disorder and with suicide attempts and explored whether risk for depression and suicide were differentially elevated in individuals with BED with or without comorbid obesity.ResultsBED shows considerable diagnostic flux with other eating disorders over time, carries high psychiatric comorbidity burden with other eating disorders (OR 85.8; 95 % CI: 61.6, 119.4), major depressive disorder (OR 7.6; 95 % CI: 6.2, 9.3), bipolar disorder (OR 7.5; 95 % CI: 4.8, 11.9), anxiety disorders (OR 5.2; 95 % CI: 4.2, 6.4), and post-traumatic stress disorder (OR 4.3; 95 % CI: 3.2, 5.7) and is associated with elevated risk for suicide attempts (OR 1.8; 95 % CI: 1.2, 2.7). Depression and suicide attempt risk were elevated in individuals with BED with and without comorbid obesity.ConclusionsConsiderable flux occurs across BED and other eating disorder diagnoses. The high psychiatric comorbidity and suicide risk underscore the severity and clinical complexity of BED.

【 授权许可】

CC BY   
© Welch et al. 2016