The Eating Disorders Genetics Initiative (EDGI): study protocol

BMC Psychiatry

Martin A. Kennedy¹  Allison L. Miller¹  Laura M. Thornton²  Jessica H. Baker²  Casey MacDermod²  Jerry Guintivano²  Lauren Harper²  Patrick F. Sullivan³  Cynthia M. Bulik⁴  Lana Cleland⁵  Jennifer Jordan⁵  Hannah Kennedy⁵  Zeynep Yilmaz⁶  Janne T. Larsen⁶  Liselotte V. Petersen⁶  Nicholas G. Martin⁷  Richard Parker⁷  Jakob Grove⁸ 

[1] Department of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand;Department of Psychiatry, University of North Carolina at Chapel Hill, CB #7160, 101 Manning Drive, 27599-7160, Chapel Hill, NC, USA;Department of Psychiatry, University of North Carolina at Chapel Hill, CB #7160, 101 Manning Drive, 27599-7160, Chapel Hill, NC, USA;Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, SE-171 77, Stockholm, Sweden;Department of Genetics, University of North Carolina at Chapel Hill, 27599, Chapel Hill, NC, USA;Department of Psychiatry, University of North Carolina at Chapel Hill, CB #7160, 101 Manning Drive, 27599-7160, Chapel Hill, NC, USA;Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, SE-171 77, Stockholm, Sweden;Department of Nutrition, University of North Carolina at Chapel Hill, 27599, Chapel Hill, NC, USA;Department of Psychological Medicine, University of Otago, Christchurch, New Zealand;National Centre for Register-based Research, Aarhus BSS, Aarhus University, Aarhus, Denmark;The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark;QIMR Berghofer Medical Research Institute, Locked Bag 2000, Royal Brisbane Hospital, 4029, Herston, QLD, Australia;The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark;Department of Biomedicine, Aarhus University, Aarhus, Denmark;Center for Genomics and Personalized Medicine, CGPM, and Center for Integrative Sequencing, iSEQ, Aarhus, Denmark;Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark;

关键词: Anorexia nervosa;    Bulimia nervosa;    Binge-eating disorder;    Eating disorders;    Genome-wide association;    Psychiatric genetics;    Psychiatric genomics consortium;    Social media;   

DOI  :  10.1186/s12888-021-03212-3

来源: Springer

【 摘 要 】

BackgroundThe Eating Disorders Genetics Initiative (EDGI) is an international investigation exploring the role of genes and environment in anorexia nervosa, bulimia nervosa, and binge-eating disorder.MethodsA total of 14,500 individuals with eating disorders and 1500 controls will be included from the United States (US), Australia (AU), New Zealand (NZ), and Denmark (DK). In the US, AU, and NZ, participants will complete comprehensive online phenotyping and will submit a saliva sample for genotyping. In DK, individuals with eating disorders will be identified by the National Patient Register, and genotyping will occur using bloodspots archived from birth. A genome-wide association study will be conducted within EDGI and via meta-analysis with other data from the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED).DiscussionEDGI represents the largest genetic study of eating disorders ever to be conducted and is designed to rapidly advance the study of the genetics of the three major eating disorders (anorexia nervosa, bulimia nervosa, and binge-eating disorder). We will explicate the genetic architecture of eating disorders relative to each other and to other psychiatric and metabolic disorders and traits. Our goal is for EDGI to deliver “actionable” findings that can be transformed into clinically meaningful insights.Trial registrationEDGI is a registered clinical trial: clinicaltrials.gov NCT04378101.

【 授权许可】

CC BY