The effect of flammer-syndrome on retinal venous pressure

BMC Ophthalmology

Research Article

Michael Baertschi¹  Maneli Mozaffarieh¹  Lei Fang² 

[1] Department of Ophthalmology, University of Basel, Mittlere Strasse 91, 4031, Basel, Switzerland;Department of Ophthalmology, University of Basel, Mittlere Strasse 91, 4031, Basel, Switzerland;Department of Biomedicine, University of Basel, Basel, Switzerland;

关键词: Glaucoma;    Retinal Vein Occlusion;    Glaucoma Patient;    Central Corneal Thickness;    Ocular Blood Flow;   

DOI  :  10.1186/1471-2415-14-121

 received in 2014-03-21, accepted in 2014-10-08,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundThe purpose of the study was to measure the retinal venous pressure (RVP) in the eyes of primary open-angle glaucoma (POAG) patients and healthy subjects with and without a Flammer-Syndrome (FS).MethodsRVP was measured in the following four groups of patients and age- and sex-matched healthy controls: (a) 15 patients with a POAG and a FS (POAG/FS+); (b) 15 patients with a POAG but without a FS (POAG/FS-); (c) 14 healthy subjects with a FS (healthy/FS+) and (d) 16 healthy subjects without a FS (healthy/FS-). RVP was measured in all participants bilaterally by means of contact lens ophthalmodynamometry. Ophthalmodynamometry is done by applying increasing pressure on the eye via a contact lens. The minimum force required to induce a venous pulsation is called ophthalmodynamometric force (ODF). The RVP is defined and calculated as the sum of ODF and intraocular pressure (IOP) [RVP = ODF + IOP].ResultsThe participants with a FS (whether patients with POAG or healthy subjects), had a significantly higher RVP compared to subjects without a FS (p = 0.0103). Patients with a POAG and FS (POAG/FS+) had a significantly higher RVP compared to patients without a FS (POAG/FS-) (p = 0.0301). There was a notable trend for a higher RVP in the healthy/FS + group compared to the healthy/FS - group, which did not reach statistical significance (p = 0.0898).ConclusionsRVP is higher in subjects with a FS, particularly in glaucoma patients. The causal relationship needs to be further evaluated.

【 授权许可】

Unknown   
© Fang et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.