Effects of Hypericum Perforatum, in a rodent model of periodontitis

BMC Complementary and Alternative Medicine

Research Article

Giancarlo Cordasco¹  Maria Galuppo¹  Irene Paterniti¹  Salvatore Cuzzocrea²  Emanuela Mazzon³  Enrico Briguglio⁴  Giacomo Oteri⁴ 

[1] Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Italy;Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Italy;Istituto Policattedra di Odontostomatologia, University of Messina, Italy;IRCCS Centro Neurolesi "Bonino-Pulejo", Messina, Italy;Istituto Policattedra di Odontostomatologia, University of Messina, Italy;

关键词: Periodontitis;    Contralateral Side;    Evans Blue;    Hypericum Perforatum;    Myeloperoxidase Activity;   

DOI  :  10.1186/1472-6882-10-73

 received in 2010-10-06, accepted in 2010-11-23,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundHypericum perforatum is a medicinal plant species containing many polyphenolic compounds, namely flavonoids and phenolic acids. In this study we evaluate the effect of Hypericum perforatum in animal model of periodontitis.MethodsPeriodontitis was induced in adult male Sprague-Dawley rats by placing a nylon thread ligature around the lower 1st molars. Hypericum perforatum was administered at the dose of 2 mg/kg os, daily for eight days. At day 8, the gingivomucosal tissue encircling the mandibular first molar was removed.ResultsPeriodontitis in rats resulted in an inflammatory process characterized by edema, neutrophil infiltration and cytokine production that was followed by the recruitment of other inflammatory cells, production of a range of inflammatory mediators such as NF-κB and iNOS expression, the nitration of tyrosine residues and activation of the nuclear enzyme poly (ADP-ribose) polymerase; apoptosis and the degree of gingivomucosal tissues injury. We report here that Hypericum perforatum exerts potent anti-inflammatory effects significantly reducing all of the parameters of inflammation as described above.ConclusionsTaken together, our results clearly demonstrate that treatment with Hypericum reduces the development of inflammation and tissue injury, events associated with periodontitis.

【 授权许可】

CC BY   
© Paterniti et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.