The Alberta Moving Beyond Breast Cancer (AMBER) Cohort Study: Recruitment, Baseline Assessment, and Description of the First 500 Participants

BMC Cancer

Research Article

Sarah MacLaughlin¹  Christine M. Friedenreich¹  Megan S. Farris¹  Rachel O’Reilly¹  Charles E. Matthews²  Jeff K. Vallance³  S. Nicole Culos-Reed⁴  John R. Mackey⁵  Kerry S. Courneya⁶  Andria R. Morielli⁶  Diane Cook⁶  Gordon J. Bell⁶  Stephanie Voaklander⁶  Margaret L. McNeely⁷ 

[1] Department of Cancer Epidemiology and Prevention Research, Alberta Health Services, Calgary, Canada;Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, USA;Faculty of Health Disciplines, Athabasca University, Athabasca, Canada;Faculty of Kinesiology, University of Calgary, Calgary, Canada;Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada;Faculty of Physical Education and Recreation, University of Alberta, 1-113 University Hall, T6G 2H9, Edmonton, AB, Canada;Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Canada;

关键词: Body composition;    Breast cancer;    Exercise;    Health-related fitness;    Lymphedema;    Physical activity;    Quality of life;    Sedentary behavior;    Survivorship;   

DOI  :  10.1186/s12885-016-2534-4

 received in 2015-12-11, accepted in 2016-07-06,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundTo our knowledge, the Alberta Moving Beyond Breast Cancer (AMBER) Study is the first and only prospective cohort study of breast cancer survivors that includes objectively-measured physical activity (PA), sedentary behavior, health-related fitness (HRF), and biologic mechanisms focused on understanding breast cancer outcomes. The purpose of the present study was to report on the feasibility of recruitment, baseline measurement completion, and the representativeness of the first 500 participants.MethodsAMBER is enrolling newly diagnosed stage I (≥T1c) to IIIc breast cancer survivors in Alberta, Canada. Baseline assessments are completed soon after diagnosis and include cardiorespiratory fitness, musculoskeletal fitness, body composition, objective and self-reported PA and sedentary behavior, lymphedema, and blood collection.ResultsBetween July 2012 and November 2014, AMBER recruited its first 500 participants from a pool of 1,447 (35 %) eligible breast cancer survivors. Baseline HRF assessments were completed on ≥85 % of participants with the exception of upper body strength. Collection of ≥4 days/week of monitoring for the Actigraph GT3X® and ActivPAL® were obtained from 90 % of participants. Completion rates were also high for blood (99 %), lymphedema (98 %), and questionnaires (95 %) including patient-reported outcomes and correlates of exercise. The first 500 participants in AMBER are an average age of 56 years, 60 % are overweight or obese, and 58 % have disease stage II or III.ConclusionDespite the modest recruitment rate and younger age, AMBER has demonstrated that many newly diagnosed breast cancer survivors are willing and able to complete a wide array of sophisticated and physically demanding HRF and PA assessments soon after diagnosis. AMBER is a unique breast cancer survivor cohort that may inform future randomized controlled trials on lifestyle and breast cancer outcomes as well as PA behavior change in breast cancer survivors. Moreover, AMBER may also inform guidelines on PA, sedentary behavior, and HRF for improving breast cancer outcomes and survivorship.

【 授权许可】

CC BY   
© The Author(s). 2016