Congenital rubella syndrome and autism spectrum disorder prevented by rubella vaccination - United States, 2001-2010

BMC Public Health

Research Article

Brynn E Berger¹  Ann Marie Navar-Boggan²  Saad B Omer³ 

[1]Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Room 7017 (CNR Building), 30322, Atlanta, Georgia, USA

[2]Departments of Pediatrics and Internal Medicine, Duke University Medical Center, Durham, North Carolina, USA

[3]Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA

[4]Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA

[5]Emory Vaccine Center, Atlanta, Georgia, USA

关键词: Autism Spectrum Disorder;    Live Birth;    Rubella;    Vaccine Safety;    Congenital Rubella Syndrome;   

DOI  :  10.1186/1471-2458-11-340

 received in 2010-10-31, accepted in 2011-05-19,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundCongenital rubella syndrome (CRS) is associated with several negative outcomes, including autism spectrum disorders (ASDs). The objective of this study was to estimate the numbers of CRS and ASD cases prevented by rubella vaccination in the United States from 2001 through 2010.MethodsPrevention estimates were calculated through simple mathematical modeling, with values of model parameters determined from published literature. Model parameters included pre-vaccine era CRS incidence, vaccine era CRS incidence, the number of live births per year, and the percentage of CRS cases presenting with an ASD.ResultsBased on our estimates, 16,600 CRS cases (range: 8300-62,250) were prevented by rubella vaccination from 2001 through 2010 in the United States. An estimated 1228 ASD cases were prevented by rubella vaccination in the United States during this time period. Simulating a slight expansion in ASD diagnostic criteria in recent decades, we estimate that a minimum of 830 ASD cases and a maximum of 6225 ASD cases were prevented.ConclusionsWe estimate that rubella vaccination prevented substantial numbers of CRS and ASD cases in the United States from 2001 through 2010. These findings provide additional incentive to maintain high measles-mumps-rubella (MMR) vaccination coverage.

【 授权许可】

CC BY   
© Berger et al; licensee BioMed Central Ltd. 2011