期刊论文详细信息
BMC Ophthalmology
Changes of retinal flow volume after intravitreal injection of bevacizumab in branch retinal vein occlusion with macular edema: a case series
Research Article
Kanako Yasuda1  Terumi Minezaki1  Masahiko Shimura1  Hidetaka Noma1  Sho Watarai1 
[1] Department of Ophthalmology, Hachioji Medical Center, Tokyo Medical University, 1163, Tatemachi, 193-0998, Hachioji, Tokyo, Japan;
关键词: Macular Edema;    Central Retinal Vein Occlusion;    Branch Retinal Vein Occlusion;    Central Macular Thickness;    Mean Blood Pressure;   
DOI  :  10.1186/s12886-016-0239-8
 received in 2015-05-22, accepted in 2016-05-17,  发布年份 2016
来源: Springer
PDF
【 摘 要 】

BackgroundAlthough intravitreal injection of bevacizumab (IVB) is effective for macular edema in patients with branch retinal vein occlusion (BRVO), the changes of retinal hemodynamics remain unclear. We investigated retinal hemodynamic changes in BRVO patients after IVB by performing laser speckle flowgraphy (LSFG).MethodsIn 35 BRVO patients with macular edema, the relative flow volume (RFV) of the retinal artery and vein passing through the optic disc was measured in both the occluded and non-occluded regions of the retina before IVB and 1 month after IVB by LSFG. The ischemic region of retina was measured with the Scion Image program and the severity of retinal ischemia was assessed by dividing the non-perfused area by the disc area.ResultsMacular edema improved significantly by 1 month after IVB. The venous RFV ratio showed a significant increase in the non-occluded region at 1 month after IVB. There was a significant negative correlation between the venous RFV ratio and the severity of retinal ischemia in the occluded region. On the other hand, arterial RFV ratio showed no significant change after IVB in either the occluded or non-occluded region. In addition, there was no significant correlation between the arterial RFV ratio and the severity of retinal ischemia in either the occluded or non-occluded region.ConclusionsThese results suggest that an increase of retinal venous outflow after IVB may possibly influence the resolution of macular edema and that the response of venous outflow after IVB depends on the severity of retinal ischemia in the occluded region.

【 授权许可】

CC BY   
© Noma et al. 2016

【 预 览 】
附件列表
Files Size Format View
RO202311098619877ZK.pdf 2799KB PDF download
【 参考文献 】
  • [1]
  • [2]
  • [3]
  • [4]
  • [5]
  • [6]
  • [7]
  • [8]
  • [9]
  • [10]
  • [11]
  • [12]
  • [13]
  • [14]
  • [15]
  • [16]
  • [17]
  • [18]
  文献评价指标  
  下载次数:3次 浏览次数:1次