Survival and prognostic factors for adrenocortical carcinoma: a single institution experience

BMC Urology

Research Article

Aleksandar Diklic¹  Ivan Paunovic¹  Vladan Zivaljevic¹  Nikola Slijepcevic¹  Zlatibor Loncar²  Branislav Olujic²  Vladimir Djukic²  Tatjana Pekmezovic³  Svetislav Tatic⁴  Dusko Dundjerovic⁴ 

[1] Centre for Endocrine Surgery, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Pasterova 2, 11000, Belgrade, Serbia;Emergency Centre, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Pasterova 2, 11000, Belgrade, Serbia;Institute of Epidemiology, Faculty of Medicine, University of Belgrade, Visegradska 26A, 11000, Belgrade, Serbia;Institute of Pathology, Faculty of Medicine, University of Belgrade, Dr Subotica 1, 11000, Belgrade, Serbia;

关键词: Adrenal gland;    Cortex;    Carcinoma;    Surgery;    Survival;    Mitotane;   

DOI  :  10.1186/s12894-015-0038-1

 received in 2015-01-19, accepted in 2015-05-19,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundAdrenocortical carcinoma (ACC) is aggressive, but rare tumours that have not been sufficiently studied. The aim of our study was to present the demographic and clinical characteristics of patients with ACC, to determine the overall survival rates, analyse the effect of prognostic factors on survival, as well as to identify favorable and unfavourable predictors of survival.MethodThe study included 72 patients (42 women and 30 men) with ACC. We analysed the prognostic value of the demographic and clinical characteristics of the patients, tumour characteristics, therapy administered and survival rates. Kaplan-Meier survival curves and the log-rank test were used to estimate the overall and specific survival probabilities and the Cox regression model was used to identify independent prognostic factors for survival.ResultsThe patients had mean age of 50 years. The 1-, 5-, and 10-year probabilities of survival in patients with ACC were 52.5 %, 41.1 %, and 16.4 %, respectively. The median survival time was 36 months. The results of multivariate Cox regression analysis showed that the presence of lymphatic metastases (HR = 7.37, 95 % CI = 2.31-23.48, p = 0.001) and therapy with mitotane (HR = 0.11, 95 % CI = 0.04-0.27, p = 0.001) were independent prognostic factors for survival.ConclusionThe presence of lymphatic metastasis is an unfavourable prognostic factor, while postoperative therapy with mitotane is a favorable prognostic factor for survival in patients with ACC.

【 授权许可】

CC BY   
© Loncar et al.; licensee BioMed Central. 2015