Burkholderia cepacia complex: clinical course in cystic fibrosis patients

BMC Pulmonary Medicine

Research Article

Rodolpho Mattos Albano¹  Orlando Carlos da Conceição Neto²  Elizabeth Andrade Marques³  Renata Wrobel Folescu Cohen⁴  Tania Wrobel Folescu⁴  Claudia Henrique da Costa⁵ 

[1] Department of Biochemistry, Universidade do Estado do Rio de Janeiro/UERJ, Rio de Janeiro, RJ, Brazil;Department of Microbiology, Hospital Central da Aeronáutica, Rio de Janeiro, RJ, Brazil;Department of Microbiology, Universidade do Estado do Rio de Janeiro/UERJ, Rio de Janeiro, RJ, Brazil;Department of Pediatric Pulmonology, Instituto Fernandes Figueira (Fundação Oswaldo Cruz, Ministério da Saúde), Av. Rui Barbosa, 716, 2nd floor, Flamengo, Zip Code: 22250-020, Rio de Janeiro, RJ, Brazil;Department of Pulmonology, Universidade do Estado do Rio de Janeiro/UERJ, Rio de Janeiro, RJ, Brazil;

关键词: Cystic fibrosis;    Burkholderia cepacia;    Respiratory Function Tests;    Body mass index;   

DOI  :  10.1186/s12890-015-0148-2

 received in 2015-07-16, accepted in 2015-11-20,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundPulmonary deterioration after B.cepacia complex (BCC) colonization has a heterogeneous pattern. The aim was to investigate the clinical outcome of BCC colonization in CF patients chronically colonized with P. aeruginosa.MethodsCF patients chronically colonized with P. aeruginosa were divided into three groups: intermittent (I), chronic (II) and no colonization (III) with BCC. Body mass index (BMI) percentile and spirometric parameters were analyzed at three different times in each group.ResultsFifty-six patients chronically colonized with P. aeruginosa were included. Of these, 27 also had evidence of BCC colonization (13 intermittent and 14 chronic). BMI percentile was significantly lower among patients chronically colonized by both P. aeruginosa and BCC. Mean values of FEV1 and FVC % were also significantly lower in these patients, both at the time of chronic BCC colonization and 24 months forward.ConclusionsChronic BCC colonization is associated with significant loss of lung function. Lower BMI might be a risk factor for chronic BCC colonization, preceding these events.

【 授权许可】

CC BY   
© Folescu et al. 2015