Symptomatic congenital cytomegalovirus disease following non-primary maternal infection: a retrospective cohort study

BMC Infectious Diseases

Research Article

Ron Bardin¹  Rinat Gabbay-Benziv¹  Eran Hadar¹  Joseph Pardo¹  Elizabeta Dorfman²  Jacob Amir³ 

[1] Helen Schneider Hospital for Women, Rabin Medical Center, 39 Zabotinski St., 49100, Petach-Tikva, Israel;Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel;Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel;Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel;Pediatrics C Department, Schneider Children’s Medical Center of Israel, Petach-Tikva, Israel;

关键词: Cytomegalovirus;    Non-primary;    Secondary;    Diagnosis;    Congenital;    Risk factors;   

DOI  :  10.1186/s12879-016-2161-3

 received in 2016-07-03, accepted in 2016-12-22,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundScarce data exist about screening, diagnosis and prognosis of non-primary Cytomegalovirus (CMV) during pregnancy. We aimed to examine antenatal diagnosis of maternal non-primary CMV infection and to identify risk factors for congenial CMV disease.MethodsRetrospective cohort of 107 neonates with congenital symptomatic CMV infection, following either primary (n = 95) or non-primary (n = 12) maternal CMV infection. We compared the groups for the manifestations and severity of congenial CMV disease, as well as for possible factors associated with the risk of developing CMV related infant morbidity.ResultsDisease severity is not similar in affected newborns, with a higher incidence of abnormal brain sonographic findings, following primary versus non-primary maternal CMV infection (76.8% vs. 8.3%, p < .001). Symptomatic congenital CMV disease following a non-primary infection is more frequent if gestational hypertensive disorders and/or gestational diabetes mellitus have ensued during pregnancy (33.3% vs. 9.9%, p <0.038), as well as if any medications were taken throughout gestation (50% vs. 16.8%, p <0.016). CMV-IgM demonstrates a low detection rate for non-primary maternal infection during pregnancy compared to primary infection (25% vs. 75.8%, p = 0.0008).ConclusionNon-primary maternal CMV infection has an impact on the neonate. Although not readily diagnosed during pregnancy, knowledge of risk factors may aid in raising clinical suspicion.

【 授权许可】

CC BY   
© The Author(s). 2017