Circumpapillary retinal nerve fiber layer thickness, anterior lamina cribrosa depth, and lamina cribrosa thickness in neovascular glaucoma secondary to proliferative diabetic retinopathy: a cross-sectional study

BMC Ophthalmology

Research Article

Yoshihiro Takamura¹  Masaru Inatani¹  Yuji Takihara¹  Satoshi Yokota² 

[1] Department of Ophthalmology, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuokashimoaizuki, Eiheiji, Yoshida, 910-1193, Fukui, Japan;Department of Ophthalmology, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuokashimoaizuki, Eiheiji, Yoshida, 910-1193, Fukui, Japan;Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Yoshidakonoe-cho, Sakyo, 606-8501, Kyoto, Japan;

关键词: Lamina cribrosa;    Neovascular glaucoma;    Optical coherence tomography;    Proliferative diabetic retinopathy;    Retinal nerve fiber layer thickness;   

DOI  :  10.1186/s12886-017-0456-9

 received in 2016-12-27, accepted in 2017-04-22,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundTo compare the lamina cribrosa between eyes with and without neovascular glaucoma (NVG) using enhanced depth imaging spectral-domain optical coherence tomography.MethodsForty-six patients with proliferative diabetic retinopathy were enrolled in this cross-sectional study. The patients were divided into two groups based on the absence or presence of NVG (the non-NVG group and the NVG group, respectively). The intraocular pressure (IOP), circumpapillary retinal nerve fiber layer (cpRNFL) thickness, anterior lamina cribrosa depth (ALD), and laminar thickness (LT) were compared between the groups.ResultsIn the non-NVG group, the mean age was 66.2 ± 2.4 (mean ± standard error) years, mean maximum IOP was 18.8 ± 1.8 mmHg, mean cpRNFL thickness was 91.2 ± 3.9 μm, mean ALD was 407.0 ± 22.9 μm, and mean LT was 155.0 ± 4.7 μm. In the NVG group, the mean age was 61.4 ± 2.1 years, mean maximum IOP was 33.1 ± 1.6 mmHg, mean cpRNFL thickness was 73.6 ± 3.4 μm, mean ALD was 403.9 ± 20.1 μm, and mean LT was 156.9 ± 4.2 μm. The IOP was significantly higher and the cpRNFL was significantly thinner in the NVG group (P < 0.001 and P = 0.002, respectively). However, the age, ALD, and LT were not statistically different between the groups (P = 0.151, 0.919, and 0.757, respectively).ConclusionsAlthough the cpRNFL was thinner, the structure of the lamina cribrosa was unchanged in the NVG eyes. Axonal loss of the retinal ganglion cells in NVG patients was prior to lamina cribrosa deformation.

【 授权许可】

CC BY   
© The Author(s). 2017