Ascorbic acid concentrations in aqueous humor after systemic vitamin C supplementation in patients with cataract: pilot study

BMC Ophthalmology

Research Article

Young-Sool Hah¹  Hye Jin Chung²  Sneha B. Sontakke²  In-Young Chung³  Seong-Jae Kim³  Seong-Wook Seo³  Ji-Myong Yoo³  Sunmi Ju⁴ 

[1] Biomedical Research Institute, Gyeongsang National University Hospital, Jinju, South Korea;College of Pharmacy and Research institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju, South Korea;Department of Ophthalmology, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, South Korea;Gyeongsang Institute of Health Science, Gyeongsang National University, Jinju, South Korea;Division of Pulmonology and Allergy, Department of Internal Medicine, Gyeongsang National University Hospital, Jinju, South Korea;

关键词: Antioxidant;    Ascorbic acid;    Aqueous humor;    Cataract;    Vitamin C;   

DOI  :  10.1186/s12886-017-0515-2

 received in 2017-03-26, accepted in 2017-07-06,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundTo measure ascorbic acid concentration in aqueous humor of patients with cataract after oral or intravenous vitamin C supplementation.MethodsForty-two eyes of 42 patients with senile cataract who underwent uncomplicated cataract surgery were enrolled. Patients (n = 14 each) were administered oral vitamin C (2 g), intravenous vitamin C (20 g) or no treatment (control group) on the day before surgery. Samples of aqueous humor (0.1 cm3) were obtained by anterior chamber aspiration at the beginning of surgery and stored at −80 °C. Ascorbic acid concentration in aqueous humor was measured by high-pressure liquid chromatography.ResultsThe mean age at surgery was 62.5 years, with no difference among the three groups. The mean ± standard deviation concentrations of ascorbic acid in aqueous humor in the control and oral and intravenous vitamin C groups were 1347 ± 331 μmol/L, 1859 ± 408 μmol/L and 2387 ± 445 μmol/L, respectively. Ascorbic acid concentration was significantly lower in the control than in the oral (P < 0.01) and intravenous (P < 0.001) vitamin C groups and was significantly higher in the intravenous than in the oral vitamin C group (P < 0.05).ConclusionsAscorbic acid concentration in aqueous humor is increased by systemic vitamin C supplementation, with intravenous administration being more effective than oral administration.

【 授权许可】

CC BY   
© The Author(s). 2017