Aqueous humor and serum 25-Hydroxyvitamin D levels in patients with cataracts

BMC Ophthalmology

Min-Chul Cho¹  Ja-Young Ahn²  Rock-Bum Kim³  Woong-Sun Yoo⁴  Seong-Jae Kim⁴ 

[1] Department of Laboratory Medicine, Gyeongsang National University Hospital and Gyeongsang National University College of Medicine;Department of Ophthalmology, Gyeongsang National University Hospital and Gyeongsang National University College of Medicine;Department of Preventive Medicine, Gyeongsang National University Hospital and Gyeongsang National University College of Medicine;Institute of Health Science, Gyeongsang National University;

关键词: 25-hydroxyvitamin D;    Aqueous humor;    Cataract;   

DOI  :  10.1186/s12886-019-1293-9

来源: DOAJ

【 摘 要 】

Abstract Background Serum 25-hydroxyvitamin D (25 (OH) D) levels are associated with various pathologic ocular conditions. Few studies have assessed 25 (OH) D concentrations in non-serum specimens, and none to date has assessed 25 (OH) D concentrations in human aqueous humor and their association with ocular diseases. This study investigated the possible correlations between 25 (OH) D concentrations in aqueous humor and serum and whether vitamin D concentrations in aqueous humor were associated with cataract. Methods This study prospectively enrolled 136 patients, including 87 with senile cataract and 49 with diabetic cataract, who underwent cataract surgery from January to November 2017. 25 (OH) D was measured in aqueous humor and serum specimens collected from all patients, and their correlation was analyzed statistically. Clinical and laboratory data, including the results of ophthalmologic examinations, were compared in the two groups of cataract patients. Results No correlation was observed between 25 (OH) D concentrations in aqueous humor and serum (P = 0.381). 25 (OH) D concentrations in aqueous humor were significantly higher in patients with diabetic than senile cataract (P = 0.006). Multivariate logistic regression analysis showed that the adjusted odds ratio for diabetic cataract for the highest compared with the lowest quartile of 25 (OH) D concentration in aqueous humor was 4.36 ng/ml (95% confidence interval [CI]: 1.33–14.34 ng/ml; P = 0.015). Multivariate linear regression analysis showed that 25(OH) D concentration in aqueous humor was 2.68 ng/ml (95% CI: 0.34–5.01 ng/ml; P = 0.025) higher in patients with diabetic than senile cataract. Conclusions 25(OH) D concentrations in aqueous humor and serum did not correlate with each other. Higher 25(OH) D level in aqueous humor was associated with diabetic cataract. These findings suggest that studies of vitamin D levels in patients with ocular conditions should include measurements of vitamin D levels in aqueous humor.

【 授权许可】

Unknown