Gastrodia elata Blume alleviates L-DOPA-induced dyskinesia by normalizing FosB and ERK activation in a 6-OHDA-lesioned Parkinson’s disease mouse model

BMC Complementary and Alternative Medicine

Research Article

Seong-Uk Park¹  Hye Hyun Yoo²  Songhee Jeon³  Jongpil Kim³  Seung-Nam Kim⁴  Ji-Yeun Park⁴  Hi-Joon Park⁴  Ah-Reum Doo⁴  Dae-Hyun Hahm⁴  Hyejung Lee⁴ 

[1] Department of Neurology and Cardiology of Korean Medicine, College of Korean Medicine, Kyung Hee University, 134-727, Seoul, Republic of Korea;Stroke and Neurological Disorders Center, Kyung Hee University Hospital at Gangdong, 149 Sangil-dong, 134-727, Gangdong-gu, Seoul, Republic of Korea;Department of Pharmacy, College of Pharmacy, Hanyang University, 426-791, Ansan-si, Gyeonggi-do, Republic of Korea;Dongguk University Research Institute of Biotechnology, Dongguk University, 3-26, Pil Dong, 100-715, Choong-Gu, Seoul, Republic of Korea;Studies of Translational Acupuncture Research (STAR), Acupuncture & Meridian Science Research Center (AMSRC), Kyung Hee University, 1 Hoegi-dong, 130-701, Dongdaemoon-gu, Seoul, Republic of Korea;

关键词: Gastrodia elata blum;    Parkinson’s disease;    Levodopa-induced dyskinesia;    ERK1/2;    FosB;   

DOI  :  10.1186/1472-6882-14-107

 received in 2013-12-16, accepted in 2014-03-11,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundGastrodia elata Blume (GEB), commonly used medicinal herb, has been reported as a promising candidate for neurodegenerative diseases such as Parkinson’s disease. The dopamine precursor, L-3,4-dihydroxyphenylalanine (L-DOPA), is the gold-standard drug for Parkinson’s disease, but long-term treatment results in the L-dopa-induced dyskinesia (LID). This study was undertaken to examine the beneficial effects of GEB on L-DOPA induced dyskinesia in 6-hydroxydopamine (6-OHDA)-induced experimental Parkinsonism.MethodsWe tested the effects of GEB on LID in 6-hydroxydopamine hydrochloride-hemiparkinsonian mice. To analyze the dyskinetic anomalies, we measured abnormal involuntary movement (AIM). Immunohistological analyses of pERK and FosB expressions in the striatum are performed to explore the mechanism of GEB on LID.ResultsThe finding of this study demonstrated that GEB (200, 400 and 800 mg/kg) alleviated L-dopa induced AIMs in a dose-dependent manner. In each integrative AIM subtype analysis, we also found that the GEB (400 and 800 mg/kg) treatment decreased L-DOPA-induced axial, limb, orolingual, and locomotive AIMs compared to the LID group. In addition, GEB normalized the abnormal LID-induced increase of pERK1/2 and FosB, the immediate early genes of LID in the striatum.ConclusionsIn conclusion, our results provide a novel insight into the pharmacological actions of GEB that could have a benefit for PD patients through the reduction of LID.

【 授权许可】

Unknown   
© Doo et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.