Effects of Shenlian extract on experimental atherosclerosis in ApoE-deficient mice based on ultrasound biomicroscopy

BMC Complementary and Alternative Medicine

Research Article

Qing Yang¹  Yan Guo¹  Wei-Yan Cai¹  Ying Chen¹  Qi Li¹  Xiao-Xin Zhu¹  Xi Chen¹  Yu-Jie Li¹  Xiao-Xi Kan¹  Xu-Cen Liu¹  Ya-Jie Wang¹  He-Fei Huang¹  Xiao-Gang Weng¹ 

[1] Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, No.16, Dongzhimen Nei Nanxiao Road, Dongcheng District, 100700, Beijing, China;

关键词: Atherosclerosis;    Ultrasound biomicroscopy;    Plaque;    Hemodynamics;    Radix Salviae miltiorrhizae;    Andrographis paniculata;   

DOI  :  10.1186/s12906-016-1449-6

 received in 2016-04-13, accepted in 2016-11-07,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThis study directly and dynamically investigated the effects of SL extract (i.e., a combination of Radix Salviae miltiorrhizae and Andrographis paniculata extract) on plaque progression in vivo by high resolution ultrasound biomicroscopy (UBM).MethodsAn atherosclerosis model was established by placing a perivascular collar on the right common carotid artery in apolipoprotein E-deficient (ApoE-/-) mice. Thickness, plaque area and local blood flow were observed by UBM, pathological changes were observed by histochemical staining, and lipid levels were measured by respective commercially available kits.ResultsCompared with the model group, the SL extract groups showed reduced wall thickness of the aortic arch (GC: P = 0.001, P = 0.002, and P < 0.001; LC: P < 0.001, P < 0.001, and P < 0.001; BC: P = 0.027, P = 0.017, and P = 0.003; respectively), which presented with retarded plaque progression of the cartoid artery with concordantly increased blood flow (P = 0.002 and P < 0.001) as visualized in vivo by UBM. Histological analysis confirmed the reduction of carotid atherosclerosis.ConclusionsThe SL extract inhibited the formation of atherosclerotic plaques in an ApoE-/- mice model by UBM analysis, and did so by effects that ameliorated local blood flow and improved blood lipid levels.

【 授权许可】

CC BY   
© The Author(s). 2016