Augmentation index is associated with coronary revascularization in patients with high Framingham risk scores: a hospital-based observational study

BMC Cardiovascular Disorders

Research Article

JoonHyouk Choi¹  Seung-Jae Joo¹  Song-Yi Kim¹  Ki-Seok Kim¹ 

[1] Division of Cardiology, Department of Internal Medicine, School of Medicine, Jeju National University, #15, Aran 13gil, 690-797, Jeju, Korea;

关键词: Atherosclerosis;    Coronary artery disease;    Risk factors;    Waves;   

DOI  :  10.1186/s12872-015-0123-0

 received in 2014-12-27, accepted in 2015-10-02,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundThis study analyzed PWAs in patients with high Framingham risk scores to determine whether PWA is predictive of coronary artery disease (CAD) severity and percutaneous coronary intervention (PCI) treatment.MethodsIn total, 310 patients were screened due to suspected CAD; 78 were excluded due to PCI history (32), atrial fibrillation (11), or acute myocardial infarction (35). The augmentation index (AIx) was analyzed immediately before coronary angiography. PCI was performed in 73 (31.5 %) patients.ResultsThe mean AIx, adjusted by heart rate (AIx@75) was different for each clinical diagnosis in the PCI group (stable angina, 30.6 ± 7.7 %; silent ischemia, 30.2 ± 8.6 %; unstable angina, 38.5 ± 8.5 %; p = 0.026). The 10-year estimate of CVD risk, based on the Framingham heart score, was 25.3 ± 6.5 % and the mean AIx@75 was 31.6 ± 8.5 % in the PCI group, significantly higher than in the non-PCI group (18.8 ± 10.2 %, p < 0.001; 27.2 ± 9.0 %, p = 0.006, respectively). An inverse correlation was observed between the minimal luminal area and AIx@75 (rho = −0.559, p = 0.010, n = 20). In ROC curve analysis of multivariate logistic regression model, higher HDL, medication of hypertension, and higher body mass index were associated with non-PCI and higher AIx@75 was associated with PCI (area under the curve, 0.764; 95 % CI: 0.701 to 0.819, z = 8.005; p <0.001).ConclusionsThe AIx@75 seemed to reflect the clinical severity of CAD and was associated with PCI in patients with a high Framingham risk score.

【 授权许可】

CC BY   
© Choi et al. 2015