RETRACTED ARTICLE: In vitro antioxidant and anticancer activity of youngZingiber officinale against human breastcarcinoma cell lines

BMC Complementary and Alternative Medicine

Research Article

Asif Iqbal¹  Shahedur Rahman¹  Faizus Salehin² 

[1] Department of Biotechnology and Genetic Engineering, Islamic University, 7003, Kushtia, Bangladesh;Department of Biotechnology and Genetic Engineering, University of Development Alternative, Dhaka, Bangladesh;

关键词: Antioxidant Activity;    Flavonoid;    Quercetin;    Anticancer Activity;    Aerial Part;   

DOI  :  10.1186/1472-6882-11-76

 received in 2011-08-07, accepted in 2011-09-20,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundGinger is one of the most important spice crops and traditionally has beenused as medicinal plant in Bangladesh. The present work is aimed to find outantioxidant and anticancer activities of two Bangladeshi ginger varieties(Fulbaria and Syedpuri) at young age grown under ambient (400 μmol/mol) andelevated (800 μmol/mol) CO2 concentrations against twohuman breast cancer cell lines (MCF-7 and MDA-MB-231).MethodsThe effects of ginger on MCF-7 and MDA-MB-231 cell lines were determined usingTBA (thiobarbituric acid) and MTT[3-(4,5-dimethylthiazolyl)-2,5-diphenyl-tetrazolium bromide] assays.Reversed-phase HPLC was used to assay flavonoids composition among Fulbaria andSyedpuri ginger varieties grown under increasing CO2concentration from 400 to 800 μmol/mol.ResultsAntioxidant activities in both varieties found increased significantly (P ≤0.05) with increasing CO2 concentration from 400 to 800μmol/mol. High antioxidant activities were observed in the rhizomes of Syedpurigrown under elevated CO2 concentration. The results showedthat enriched ginger extract (rhizomes) exhibited the highest anticancer activityon MCF-7 cancer cells with IC50 values of 34.8 and 25.7μg/ml for Fulbaria and Syedpuri respectively. IC50 valuesfor MDA-MB-231 exhibition were 32.53 and 30.20 μg/ml for rhizomes extract ofFulbaria and Syedpuri accordingly.ConclusionsFulbaria and Syedpuri possess antioxidant and anticancer properties especiallywhen grown under elevated CO2 concentration. The use ofginger grown under elevated CO2 concentration may havepotential in the treatment and prevention of cancer.

【 授权许可】

CC BY   
© Rahman et al; licensee BioMed Central Ltd. 2011