Compliance and treatment satisfaction of post menopausal women treated for osteoporosis. Compliance with osteoporosis treatment

BMC Women's Health

Research Article

Dominique Huas¹  Anne-Françoise Gaudin²  François-Emery Cotté³  Véronique Berger⁴  Chantal Rousseaux⁴  Francis Blotman⁵  Françoise Debiais⁶  Bernard Cortet⁷  Florence Mercier⁸ 

[1] Department of General Practice, UFR Paris 7, Paris, France;Laboratoire GlaxoSmithKline, Marly le Roi, France;Laboratoire GlaxoSmithKline, Marly le Roi, France;CERMES, IFR69, INSERM U750, National Institute of Health and Medical Research, Villejuif, France;Nukléus, Paris, France;Rheumatology Department, Montpellier University Hospital, Montpellier, France;Rheumatology Department, Poitiers University Hospital, Poitiers, France;Rheumatology Department, Roger Salengro Hospital, Lille, France;STAT-Process, Port-Mort, France;

关键词: Osteoporosis;    Treatment Satisfaction;    Osteoporosis Treatment;    Treatment Compliance;    Pill Count;   

DOI  :  10.1186/1472-6874-10-26

 received in 2010-01-25, accepted in 2010-08-20,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundAdherence to anti-osteoporosis treatments is poor, exposing treated women to increased fracture risk. Determinants of poor adherence are poorly understood. The study aims to determine physician- and patient- rated treatment compliance with osteoporosis treatments and to evaluate factors influencing compliance.MethodsThis was an observational, cross-sectional pharmacoepidemiological study with a randomly-selected sample of 420 GPs, 154 rheumatologists and 110 gynaecologists practicing in France. Investigators included post-menopausal women with a diagnosis of osteoporosis and a treatment initiated in the previous six months. Investigators completed a questionnaire on clinical features, treatments and medical history, and on patient compliance. Patients completed a questionnaire on sociodemographic features, lifestyle, attitudes and knowledge about osteoporosis, treatment compliance, treatment satisfaction and quality of life. Treatment compliance was evaluated with the Morisky Medication-taking Adherence Scale. Variables collected in the questionnaires were evaluated for association with compliance using multivariate logistic regression analysis.Results785 women were evaluated. Physicians considered 95.4% of the sample to be compliant, but only 65.5% of women considered themselves compliant. The correlation between patient and physician perceptions of compliance was low (κ: 0.11 [95% CI: 0.06 to 0.16]). Patient-rated compliance was highest for monthly bisphosphonates (79.7%) and lowest for hormone substitution therapy (50.0%). Six variables were associated with compliance: treatment administration frequency, perceptions of long-term treatment acceptability, perceptions of health consequences of osteoporosis, perceptions of knowledge about osteoporosis, exercise and mental quality of life.ConclusionCompliance to anti-osteoporosis treatments is poor. Reduction of dosing regimen frequency and patient education may be useful ways of improving compliance.

【 授权许可】

Unknown   
© Huas et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.