The IGCA staging system is more accurate than AJCC7 system in stratifying survival of patients with gastric cancer in stage III

BMC Cancer

Research Article

Yong Fang¹  Xuefei Wang¹  Xinyu Qin¹  Yihong Sun¹  Jing Qin¹  Weidong Chen¹  Ping Shu¹  Kuntang Shen¹  Zhenbin Shen¹  Fenglin Liu¹  Hongshan Wang¹ 

[1] Department of General Surgery, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, 200032, Shanghai, People’s Republic of China;

关键词: Gastric cancer;    Lymph node;    TNM staging;    Prognosis;    Overall survival;   

DOI  :  10.1186/s12885-017-3235-3

 received in 2016-12-06, accepted in 2017-03-24,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundA new staging system recently proposed by the IGCA has demonstrated a better capacity of stratifying different prognoses for gastric cancer than the 7th edition AJCC staging system (AJCC7). The aim of this study was to evaluate the efficacy of the IGCA system in Chinese patients.MethodsMedical records of patients with gastric cancer who received curative surgery in our center from January 2003 to December 2011 were reviewed retrospectively. All the lesions were staged according to both AJCC7 and IGCA staging systems. Overall survival (OS) of the patients was used as the observation endpoint.ResultsOne thousand five hundred twenty-six cases were included in this study. By comparing the AJCC7 system with the IGCA systems, 395 cases were stratified into different stages, most of which were in stage III. The IGCA system could better stratify stage IIIB and IIIC patients (5-year OS, 38.1% vs. 29.0%; P = 0.005) than the AJCC7 system (5-year OS, 38.2% vs. 35.9%; P = 0.148). T3N3bM0, T4aN2M0 and T4aN3bM0 made up 97.5% (385/395) of the stage shift. T3N3bM0, which was stratified to stage IIIB in the AJCC7 system, showed a significant poorer prognosis than T4aN2M0 and T4aN3aM0, which were staged to IIIB and IIIC in the same system. The improper staging was revised in the IGCA staging system.ConclusionsThe IGCA staging system can stratify stage III gastric cancer patients more properly than the AJCC7 system.

【 授权许可】

CC BY   
© The Author(s). 2017