Prostate-specific antigen (PSA) screening and follow-up investigations in Māori and non-Māori men in New Zealand

BMC Family Practice

Research Article

Alistair Stewart¹  Nina Scott²  Michael Holmes³  Charis Brown⁴  Fraser Hodgson⁴  Ross Lawrenson⁴  Zuzana Obertová⁵ 

[1] School of Population Health, University of Auckland, Auckland, New Zealand;Te Puna Oranga, Waikato District Health Board, Hamilton, New Zealand;Urology Department, Waikato Hospital, Hamilton, New Zealand;Waikato Clinical School, University of Auckland, Hamilton, New Zealand;Waikato Clinical School, University of Auckland, Hamilton, New Zealand;Waikato Clinical School, Peter Rothwell Academic Centre, Private Bag 3200, 3240, Hamilton, New Zealand;

关键词: Prostate cancer;    Ethnicity;    Inequality;    Biopsy;    Specialist referral;   

DOI  :  10.1186/1471-2296-15-145

 received in 2014-04-01, accepted in 2014-08-18,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundMāori men in New Zealand have higher mortality from prostate cancer, despite having lower incidence rates. The objective of this study was to examine patterns of screening for prostate cancer in primary care and follow-up investigations after an elevated prostate-specific antigen (PSA) result in Māori and non-Māori men in order to help explain the observed differences in incidence and mortality.MethodsMen aged 40+ years were identified from 31 general practices across the Midland Cancer Network region. Computerised practice records were cross-referenced with laboratory data to determine the number and value of PSA tests undertaken between January 2007 and December 2010. Screening rates were calculated for the year 2010 by age, ethnicity, and practice. For men with an elevated PSA result information on specialist referrals and biopsy was extracted from practice records. Practice characteristics were assessed with respect to screening rates for Māori and non-Māori men.ResultsThe final study population included 34,960 men aged 40+ years; 14% were Māori. Māori men were less likely to be screened in 2010 compared with non-Māori men (Mantel Haenszel (M-H) age-adjusted risk ratio (RR), 0.52 [95% CI, 0.48, 0.56]). When screened, Māori men were more than twice as likely to have an elevated PSA result compared with non-Māori men (M-H age-adjusted RR, 2.16 [95% CI, 1.42, 3.31]). There were no significant differences between Māori and non-Māori men in the rate of follow-up investigations and cancer detection. Māori provider practices showed equal screening rates for Māori and non-Māori men, but they were also the practices with the lowest overall screening rates.ConclusionsMāori men were half as likely to be screened compared to non-Māori men. This probably explains the lower reported incidence of prostate cancer for Māori men. Practice characteristics had a major influence on screening rates. Large variation in screening behaviour among practices and differences in follow-up investigations for men with an elevated PSA result seems to reflect the uncertainty among GPs regarding PSA screening and management.

【 授权许可】

CC BY   
© Obertová et al.; licensee BioMed Central Ltd. 2014