The role of osmolality in saline fluid nebulization after tracheostomy: time for changing?

BMC Pulmonary Medicine

Research Article

Haiying Zhang¹  Feifei Cui¹  Meifen Shen¹  Zunjia Wen²  Binbin Mei²  Chao Wu² 

[1] Neurosurgery Department of First Hospital Affiliated to Soochow University, No. 188 Shizi Street, Gusu District, Su Zhou, Jiangsu Province, People’s Republic of China;Nursing School of Soochow University, Su Zhou, People’s Republic of China;

关键词: Care;    Complication;    Nebulization;    Osmolality;    Saline;    Tracheostomy;   

DOI  :  10.1186/s12890-016-0342-x

 received in 2016-08-22, accepted in 2016-12-02,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundSaline fluid nebulization is highly recommend to combat the complications following tracheostomy, yet the understandings on the role of osmolality in saline solution for nebulization remain unclear.ObjectivesTo investigate the biological changes in the early stage after tracheostomy, to verify the efficacy of saline fluid nebulization and explore the potential role of osmolality of saline nebulization after tracheostomy.MethodsSprague-Dawley rats undergone tracheostomy were taken for study model, the sputum viscosity was detected by rotational viscometer, the expressions of TNF-α, AQP4 in bronchoalveolar lavage fluid were assessed by western blot analysis, and the histological changes in endothelium were evaluated by HE staining and scanning electron microscopy (SEM).ResultsStudy results revealed that tracheostomy gave rise to the increase of sputum viscosity, TNF-α and AQP4 expression, mucosa and cilia damage, yet the saline fluid nebulization could significantly decrease the changes of those indicators, besides, the hypertonic, isotonic and hypertonic saline nebulization produced different efficacy.ConclusionsOsmolality plays an important role in the saline fluid nebulization after tracheostomy, and 3% saline fluid nebulization seems to be more beneficial, further studies on the role of osmolality in saline fluid nebulization are warranted.

【 授权许可】

CC BY   
© The Author(s). 2016