The relationship between attention deficit hyperactivity disorder and premature infants in Taiwanese: a case control study

BMC Psychiatry

Research Article

Yu-Shu Huang¹  Fan-Ming Hwang²  Ming-Horng Tsai³  Shih-Ming Chu⁴  Jen-Fu Hsu⁴  Hsuan Rong Huang⁴ 

[1] Department of Child Psychiatry and Sleep Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan;College of Medicine, Chang Gung University, Taoyuan, Taiwan;Department of Child Psychiatry and Sleep Center, Chang Gung Memorial Hospital, 5, Fu-Shing St., 333, Kwei-Shan, Taoyuan, Taiwan;Department of Education, National Chia-Yi University, Chiayi, Taiwan;Division of Pediatric Neonatology and Hematology/Oncology, Chang Gung Memorial Hospital, Yunlin, Taiwan;Chang Gung Institute of Technology, Chiayi, Taiwan;Division of Pediatric Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan;College of Medicine, Chang Gung University, Taoyuan, Taiwan;

关键词: Premature infant;    Attention-deficit/hyperactivity disorder;    Behavioral disorder;    DSM-IV;    Gestational age;   

DOI  :  10.1186/1471-244X-12-85

 received in 2011-06-08, accepted in 2012-07-23,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundPreterm survivors from the neonatal intensive care unit (NICU) are considered to be at risk for some neurobehavioral disorders such as attention-deficit/hyperactivity disorder (ADHD). The current study aimed to explore the relationship between ADHD and premature infants in Taiwan.MethodsA total of 195 children (157 males and 38 females) diagnosed with ADHD based on DSM-IV and aged between 6 to 12 years and a control group of 212 (164 males, 48 females) age- and sex-matched healthy children were enrolled. The ADHD-Rating scale and CGI severity were performed by child psychiatrists. Demographic data of the children, including birth history, perinatal neurological and respiratory problems were collected to facilitate the investigation of whether a correlation exists between ADHD and prematurity.ResultsThe ADHD group had a significantly higher rate of prematurity and significantly higher rate of low birth body weight (defined as <2500 g) than the control group (both P = 0.003). Pearson correlation showed a significantly negative correlation between gestational age and ADHD-RS score, inattentive score, hyperactivity and CGI-S score (P = 0.004, 0.013, 0.015 and 0.002, respectively). However, only a CGI-S score (P = 0.018) showed a significantly correlation between low birth weight and ADHD.ConclusionsPremature infants have significantly more severe symptoms of ADHD at school age and they were highly correlated. Further study is necessary to determine the main effect and pathogenesis of moderate as well as extreme preterm birth on the development of ADHD.

【 授权许可】

Unknown   
© Chu et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.