The relationship between attention deficit hyperactivity disorder and premature infants in Taiwanese: a case control study

BMC Psychiatry

Yu-Shu Huang²  Hsuan Rong Huang³  Jen-Fu Hsu³  Fan-Ming Hwang¹  Ming-Horng Tsai⁴  Shih-Ming Chu³ 

[1] Department of Education, National Chia-Yi University, Chiayi, Taiwan;Department of Child Psychiatry and Sleep Center, Chang Gung Memorial Hospital, 5, Fu-Shing St., Kwei-Shan, Taoyuan, 333, Taiwan;College of Medicine, Chang Gung University, Taoyuan, Taiwan;Chang Gung Institute of Technology, Chiayi, Taiwan

关键词: Gestational age;    DSM-IV;    Behavioral disorder;    Attention-deficit/hyperactivity disorder;    Premature infant;   

Others  :  1124346
DOI  :  10.1186/1471-244X-12-85

 received in 2011-06-08, accepted in 2012-07-23,  发布年份 2012

【 摘 要 】

Background

Preterm survivors from the neonatal intensive care unit (NICU) are considered to be at risk for some neurobehavioral disorders such as attention-deficit/hyperactivity disorder (ADHD). The current study aimed to explore the relationship between ADHD and premature infants in Taiwan.

Methods

A total of 195 children (157 males and 38 females) diagnosed with ADHD based on DSM-IV and aged between 6 to 12 years and a control group of 212 (164 males, 48 females) age- and sex-matched healthy children were enrolled. The ADHD-Rating scale and CGI severity were performed by child psychiatrists. Demographic data of the children, including birth history, perinatal neurological and respiratory problems were collected to facilitate the investigation of whether a correlation exists between ADHD and prematurity.

Results

The ADHD group had a significantly higher rate of prematurity and significantly higher rate of low birth body weight (defined as <2500 g) than the control group (both P = 0.003). Pearson correlation showed a significantly negative correlation between gestational age and ADHD-RS score, inattentive score, hyperactivity and CGI-S score (P = 0.004, 0.013, 0.015 and 0.002, respectively). However, only a CGI-S score (P = 0.018) showed a significantly correlation between low birth weight and ADHD.

Conclusions

Premature infants have significantly more severe symptoms of ADHD at school age and they were highly correlated. Further study is necessary to determine the main effect and pathogenesis of moderate as well as extreme preterm birth on the development of ADHD.

【 授权许可】

   
2012 Chu et al.; licensee BioMed Central Ltd.

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