Biochemical comparison of osteoarthritic knees with and without effusion

BMC Musculoskeletal Disorders

Research Article

Michael R Sitler¹  Mary F Barbe²  Mamta Amin²  Easwaran Balasubramanian³  Nicole M Cattano⁴  Jeffrey B Driban⁵ 

[1] College of Health Professions and Social Work, Temple University, 3307 N. Broad Street, Suite 300, 19140, Philadelphia, PA, USA;Department of Anatomy and Cell Biology, Temple University School of Medicine, 3500 N. Broad Street, 19140, Philadelphia, PA, USA;Department of Orthopaedic Surgery and Sports Medicine, Temple University, 3509 N. Broad Street, 5th Floor Boyer Pavilion, 19140, Philadelphia, PA, USA;Department of Sports Medicine, West Chester University of Pennsylvania, 855 S. New Street, 313 Sturzebecker HSC, 19383, West Chester, PA, USA;Division of Rheumatology, Tufts Medical Center, Box 406, 800 Washington Street, 02111, Boston, MA, USA;

关键词: Synovial Fluid;    Synovitis;    Biochemical Difference;    Synovial Fluid Sample;    Knee Effusion;   

DOI  :  10.1186/1471-2474-12-273

 received in 2011-05-17, accepted in 2011-11-28,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundSeveral symptom-relieving interventions have been shown to be efficacious among osteoarthritis (OA) patients with knee effusion; however, not every symptomatic knee OA patient has clinical effusion. Results may be over-generalized since it is unclear if effused knees represent a unique pathological condition or subset compared to knees without effusion. The primary purpose of this study was to determine if biochemical differences existed between OA knees with and without effusion.MethodsThe present cross-sectional study consisted of 22 volunteers (11 with knee effusion, 11 without knee effusion) with confirmed late-stage radiographic knee OA (Kellgren-Lawrence score ≥ 3). Synovial fluid samples were collected and analyzed using a custom multiplex enzyme-linked immunosorbent assay to determine eight specific biomarker concentrations (e.g., catabolic, anabolic).ResultsMatrix metalloproteinase (MMP)-3, tissue inhibitor of MMPs (TIMP)-1, TIMP-2, and interleukin-10 were significantly higher in the knees with effusion than in the knees without effusion.ConclusionsThe biochemical differences that existed between knees with and without effusion provide support that OA subsets may exist, characterized by distinct biochemical characteristics and clinical findings (e.g., effusion).

【 授权许可】

Unknown   
© Cattano et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.