The Peripheral Arterial disease study (PERART/ARTPER): prevalence and risk factors in the general population

BMC Public Health

Research Article

Amparo Sancho¹  José Miguel Baena-Díez²  Carlos Albaladejo³  Marta Sorribes⁴  Marisa Vicheto⁵  María Teresa Alzamora⁶  Rosa Forés⁷  Judith Llussà⁸  María Dolores Reina⁹  Guillem Pera^1,10  Pere Toran^1,10 

[1] Primary Healthcare Centre Can Mariné, Institut Català de la Salut, Santa Coloma de Gramenet, Spain;Primary Healthcare Centre La Marina, Institut Català de la Salut, Barcelona, Spain;Primary Healthcare Centre Llefià, Institut Català de la Salut Badalona, Badalona, Spain;Primary Healthcare Centre Numància, Institut Català de la Salut, Barcelona, Spain;Primary Healthcare Centre Riu Nord-Riu Sud, Institut Català de la Salut, Santa Coloma de Gramenet, Spain;Primary Healthcare Centre Riu Nord-Riu Sud, Institut Català de la Salut, Santa Coloma de Gramenet, Spain;Department of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain;Research Unit Metropolitana Nord, ICS-IDIAP Jordi Gol, Mataró, Spain;Primary Healthcare Centre Riu Nord-Riu Sud, Institut Català de la Salut, Santa Coloma de Gramenet, Spain;Research Unit Metropolitana Nord, ICS-IDIAP Jordi Gol, Mataró, Spain;Primary Healthcare Centre Sant Roc, Institut Català de la Salut, Badalona, Spain;Primary Healthcare Centre Santa Coloma de Gramenet, Institut Català de la Salut, Santa Coloma de Gramenet, Spain;Research Unit Metropolitana Nord, ICS-IDIAP Jordi Gol, Mataró, Spain;

关键词: Peripheral Arterial Disease;    Transient Ischaemic Attack;    Intermittent Claudication;    Primary Care Centre;    Akaike Information Criterion;   

DOI  :  10.1186/1471-2458-10-38

 received in 2009-08-13, accepted in 2010-01-27,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundThe early diagnosis of atherosclerotic disease is essential for developing preventive strategies in populations at high risk and acting when the disease is still asymptomatic. A low ankle-arm index is a good marker of vascular events and may be diminished without presenting symptomatology (silent peripheral arterial disease). The aim of the study is to know the prevalence and associated risk factors of peripheral arterial disease in the general population.MethodsWe performed a cross-sectional, multicentre, population-based study in 3786 individuals >49 years, randomly selected in 28 primary care centres in Barcelona (Spain). Peripheral arterial disease was evaluated using the ankle-arm index. Values < 0.9 were considered as peripheral arterial disease.ResultsThe prevalence (95% confidence interval) of peripheral arterial disease was 7.6% (6.7-8.4), (males 10.2% (9.2-11.2), females 5.3% (4.6-6.0); p < 0.001).Multivariate analysis showed the following risk factors: male sex [odds ratio (OR) 1.62; 95% confidence interval 1.01-2.59]; age OR 2.00 per 10 years (1.64-2.44); inability to perform physical activity [OR 1.77 (1.17-2.68) for mild limitation to OR 7.08 (2.61-19.16) for breathless performing any activity]; smoking [OR 2.19 (1.34-3.58) for former smokers and OR 3.83 (2.23-6.58) for current smokers]; hypertension OR 1.85 (1.29-2.65); diabetes OR 2.01 (1.42-2.83); previous cardiovascular disease OR 2.19 (1.52-3.15); hypercholesterolemia OR 1.55 (1.11-2.18); hypertriglyceridemia OR 1.55 (1.10-2.19). Body mass index ≥25 Kg/m2 OR 0.57 (0.38-0.87) and walking >7 hours/week OR 0.67 (0.49-0.94) were found as protector factors.ConclusionsThe prevalence of peripheral arterial disease is low, higher in males and increases with age in both sexes. In addition to previously described risk factors we found a protector effect in physical exercise and overweight.

【 授权许可】

CC BY   
© Alzamora et al; licensee BioMed Central Ltd. 2010