RETRACTED ARTICLE: Peripheral bloodmono-nuclear cells implantation in patients with peripheral arterial disease: a pilotstudy for clinical and biochemical outcome of neoangiogenesis

BMC Surgery

Research Article

Rita Compagna¹  Antonio Braucci¹  Roberto Rossi¹  Giovanni Martino¹  Bruno Amato¹  Tommaso Bianco¹  Guido Coretti¹  Gianni Antonio Della Corte¹  Giovanni Aprea¹  Pio Zeppa²  Claudio Terranova³  Alessandro Puzziello⁴ 

[1] Department of General, Geriatric, Oncologic Surgery and Advanced Technologies University of Naples Federico II, Via S. Pansini,5, 801311, Napoli, Italy;Department of Medicine and Surgery, University of Salerno, Italy;Department of Molecular Medicine, Padova University Hospital, Via Giustiniani n.2, 35126, Italy, Padova, Italy;Dept of Medical and Surgical Sciences, University Magna Graecia, Catanzaro, Italy;

关键词: Peripheral Arterial Disease;    Endothelial Progenitor;    Limb Ischemia;    Critical Limb Ischemia;    Intermittent Claudication;   

DOI  :  10.1186/1471-2482-12-S1-S1

来源: Springer

【 摘 要 】

BackgroundSubstantial progresses in the management of peripheral arterial disease (PAD)have been made in the past two decades. Progress in the understanding of theendothelial-platelet interaction during health and disease state has resulted inbetter antiplatelet drugs that can prevent platelet aggregation, activation andthrombosis during angioplasty and stenting. A role in physiological andpathological angiogenesis in adults has been recently shown in bone marrow–derivedcirculating endothelial progenitors (BM-DCEPs) identified in the peripheral blood.These findings have paved the way for the development of therapeuticneovascularization techniques using endothelial progenitors.MethodsThis pilot study includes five patients, aged 60 to 75, with a history ofclaudication and recruited from September 2010 to February 2011 at the A.O.U.Federico II of Naples.PBMNCs have been implanted three times in the limb with the worst ABI value inall the patients included in the study.The clinical follow up was performed during the subsequent 12 months from thebeginning of the treatment.ResultsIn four patients there was a regression of ulcerative lesions.One patient’s condition improved after the first implantation but later didnot respond to the further treatments.All patients achieved a pain relief as judged by the numeric pain scale. Painrelief remained satisfactory in three patients for one year. Pain graduallyreturned to the pre-treatment level in two patients.All patients referred an ameliorating in their quality of life expressed evenby an improvement in claudication free walking distance.These improvements are reflected also by intra-arterial digital subtractionangiography (IADSA) that shows an improvement of arterial vascularization.ConclusionsThe data from this study suggest an efficacy of BM-DCEPs implantation in termsof improvement of the vascularization and quality of life in patients affected byPeripheral Arterial Disease. Nevertheless a double-blind placebo-controlled studyis needed to confirm our findings.

【 授权许可】

CC BY   
© Amato et al; licensee BioMed Central Ltd. 2012