Independent association of HbA1c and nonalcoholic fatty liver disease in an elderly Chinese population

BMC Gastroenterology

Research Article

Youming Li¹  Han Ma¹  Chengfu Xu¹  Chaohui Yu¹  Lei Xu²  Min Miao³ 

[1] Department of Gastroenterology, the First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, 310003, Hangzhou, China;Department of Gastroenterology, the First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, 310003, Hangzhou, China;Department of Gastroenterology, Ningbo No. 1 Hospital, Ningbo, China;Department of Internal Medicine, Zhenhai Lianhua Hospital, Ningbo, China;

关键词: Fatty liver;    Glycosylated hemoglobin;    Elderly;    Obesity;   

DOI  :  10.1186/1471-230X-13-3

 received in 2012-08-23, accepted in 2012-12-14,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundTo investigate the association between serum glycosylated hemoglobin (HbA1c) levels and nonalcoholic fatty liver disease (NAFLD) in an elderly Chinese population.MethodsA cross-sectional study was performed among the 949 retired elderly employees of Zhenhai Refining & Chemical Company Ltd., Ningbo, China.ResultsA total of 257 (27.08%) subjects fulfilled the diagnostic criteria of NAFLD, and NAFLD patients had significantly higher serum HbA1c levels than controls (P <0.001). The prevalence of NAFLD was significantly higher in subjects with increased serum HbA1c level (HbA1c ≥6.5%) than in those with normal range of serum HbA1c level (51.71% vs. 25.20%; P <0.001), and the prevalence increased along with progressively higher serum HbA1c levels (P for trend <0.001). Stepwise logistic regression analysis showed that serum HbA1c level was significantly associated with the risk for NAFLD (odds ratio: 1.547, 95% confidence interval: 1.054 – 2.270; P =0.026).ConclusionsOur results suggest that serum HbA1c level is associated with NAFLD, and increased serum HbA1c level is an independent risk factor for NAFLD in elderly Chinese.

【 授权许可】

Unknown   
© Ma et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.