Association between serum uric acid levels and cardiovascular disease in middle-aged and elderly Chinese individuals

BMC Cardiovascular Disorders

Research Article

Guang Ning¹  Yin Xing²  Shuai Lu²  Qun Shi²  Hongxia Gu²  Qing Su³  Li Qin³  Zhen Yang³  Xiaoyong Li³  Rui Li⁴ 

[1] Department of Endocrinology, Ruijin hospital, School of medicine, Shanghai Jiaotong University, Shanghai, China;Department of Endocrinology, Xinhua hospital Chongming branch, School of medicine, Shanghai Jiaotong University, Shanghai, China;Department of Endocrinology, Xinhua hospital, School of medicine, Shanghai Jiaotong University, Kongjiang Road, 1665, Shanghai, China;Shanghai Municipal Center For Disease Control And Prevention, Shanghai, China;

关键词: Uric acid;    Cardiovascular disease;    Metabolic syndrome;    Stroke;    Coronary heart disease;   

DOI  :  10.1186/1471-2261-14-26

 received in 2013-01-28, accepted in 2014-02-11,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundA link between uric acid (UA) levels and cardiovascular diseases has been previously reported. However, its importance as a risk factor is still controversial. This study sought to determine whether elevated serum uric acid levels are associated with cardiovascular disease (CVD) in middle-aged and elderly Chinese individuals.MethodsWe conducted a population-based cross-sectional study in Shanghai, with a total of 8510 participants aged ≥40 years. The CVD included diagnosed coronary heart disease (CHD) and stroke. MetS was defined according to the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian Americans.ResultsUric acid levels were positively associated with BMI, waist circumference, triglycerides, systolic blood pressure, diastolic blood pressure, glycohemoglobin, fasting plasma glucose, postprandial 2-hour plasma glucose (all P < 0.05), and negatively associated with HDL-cholesterol (P < 0.001). The prevalence of CVD significantly increased with increasing quartiles of UA in those without MetS group (p trend < 0.001), but not necessarily increased in those with MetS. After adjustment for metabolic syndrome and other cardiovascular risk factors, multivariate logistic regression analysis showed that odds ratios (OR) for CHD, stroke, and CVD in those in the fourth quartiles were 2.34 (95% confidence interval [CI] 1.73 to 3.45), 2.18 (95% CI 1.86 to 3.28), and 2.16 (95% CI 1.80 to 3.29), respectively, compared with those in the first quartile of UA.ConclusionsElevated serum uric acid level was associated with CVD, independent of conventional cardiovascular disease risk factors and metabolic syndrome.

【 授权许可】

Unknown   
© Qin et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.