Impact of air pollution on pulmonary function and respiratory symptoms in children. Longitudinal repeated-measures study

BMC Pulmonary Medicine

Research Article

Alfonso Garcia¹  Jose R Perez²  Rocío Chapela²  Victor Miranda³  Norma Amador⁴  Benigno Linares⁵  Juan M Guizar⁶ 

[1] Departamento de Medicina y Nutrición, Universidad de Guanajuato. 20 de Enero 929 Col. Obregón Z.C., 37320, León, Mexico;Instituto Nacional de Enfermedades Respiratorias, 4502, Tlalpan, DF, Mexico;Instituto Nacional de Salud Pública, Cuernavaca, Morelos, Mexico;Unidad Médica de Alta Especialidad No. 1, Instituto Mexicano del Seguro Social. López Mateos e Insurgentes s/n Col. Paraísos Z.C., 37320, León, Mexico;Unidad Médica de Alta Especialidad No. 1, Instituto Mexicano del Seguro Social. López Mateos e Insurgentes s/n Col. Paraísos Z.C., 37320, León, Mexico;Departamento de Medicina y Nutrición, Universidad de Guanajuato. 20 de Enero 929 Col. Obregón Z.C., 37320, León, Mexico;Unidad Médica de Alta Especialidad No. 1, Instituto Mexicano del Seguro Social. López Mateos e Insurgentes s/n Col. Paraísos Z.C., 37320, León, Mexico;Universidad De La Salle Bajío, León Gto, Mexico;

关键词: Lung Function;    Respiratory Symptom;    Force Vital Capacity;    Peak Expiratory Flow;    PM10 Level;   

DOI  :  10.1186/1471-2466-10-62

 received in 2009-05-07, accepted in 2010-11-24,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundSalamanca, Mexico occupied fourth place nationally in contaminating emissions. The aim of the study was to determine the impact of air pollution on the frequency of pulmonary function alterations and respiratory symptoms in school-age children in a longitudinal repeated-measures study.MethodsWe recruited a cohort of 464 children from 6 to 14 years of age, from two schools differing in distance from the major stationary air pollution sources. Spirometry, respiratory symptoms and air pollutants (O3, SO2, NO, NO2, NOx, PM10,) were obtained for each season. Mixed models for continuous variables and multilevel logistic regression for respiratory symptoms were fitted taking into account seasonal variations in health effects according to air pollution levels.ResultsAbnormalities in lung function and frequency of respiratory symptoms were higher in the school closer to major stationary air pollution sources than in the distant school. However, in winter differences on health disappeared. The principal alteration in lung function was the obstructive type, which frequency was greater in those students with greater exposure (10.4% vs. 5.3%; OR = 1.95, 95% CI 1.0-3.7), followed by the mixed pattern also more frequent in the same students (4.1% vs. 0.9%; OR = 4.69, 95% CI, 1.0-21.1). PM10 levels were the most consistent factor with a negative relationship with FVC, FEV1 and PEF but with a positive relationship with FEV1/FVC coefficient according to its change per 3-month period.ConclusionsStudents from the school closer to major stationary air pollution sources had in general more respiratory symptoms than those from the distant school. However, in winter air pollution was generalized in this city and differences in health disappeared. PM10 levels were the most consistent factor related to pulmonary function according, to its change per 3-month period.

【 授权许可】

Unknown   
© Linares et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.