Persistent Chlamydia Pneumoniae serology is related to decline in lung function in women but not in men. Effect of persistent Chlamydia pneumoniae infection on lung function

BMC Pulmonary Medicine

Research Article

Isleifur Olafsson¹  Christer Janson²  Bryndis Benediktsdottir³  Bjarni Thjodleifsson⁴  Thorarinn Gislason⁴  Thor Aspelund⁵  Vilmundur Guðnason⁵ 

[1] Department of Clinical Biochemistry, Landspitali University Hospital, Reykjavik, Iceland;Respiratory Medicine and Allergology, Uppsala University, Uppsala, Sweden;University of Iceland, Faculty of Medicine, Reykjavik, Iceland;University of Iceland, Faculty of Medicine, Reykjavik, Iceland;Department of Medicine Landspitali, University Hospital, Reykjavik, Iceland;University of Iceland, Faculty of Medicine, Reykjavik, Iceland;Icelandic Heart Association, Kopavogur, Iceland;

关键词: Chronic Obstructive Pulmonary Disease;    Lung Function;    Force Vital Capacity;    Persistent Infection;    Bronchial Hyperresponsiveness;   

DOI  :  10.1186/1471-2466-10-44

 received in 2010-04-08, accepted in 2010-08-25,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundChlamydia pneumoniae (C pn) infection causes an acute inflammation in the respiratory system that may become persistent, but little is known about the long-term respiratory effects of C pn infections. Aim: To estimate the long term respiratory effects of C pn with change in forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) as a main outcome variable.MethodsThe study comprised of 1109 subjects (500 men and 609 women, mean age 28 ± 6 years) that participated in the Reykjavik Heart Study of the Young. Spirometry and blood samples for measurements of IgG antibodies for C pn were done at inclusion and at the end of the follow-up period (mean follow-up time 27 ± 4 years).ResultsHaving IgG against C pn at both examinations was significantly associated to a larger decrease in FEV1 (6 mL/year) and FVC (7 mL/year) in women but not in men. In women the association between C pn and larger FEV1 decline was only found in women that smoked at baseline where having C pn IgG was associated with 10 mL/year decline compared to smokers without C pn IgG. These results were still significant after adjustment for age, smoking and change in body weight.ConclusionOur results indicate that persistent C pn serology is related to increased decline in lung function in women but not in men. This effect was, however, primarily found in smoking women. This study is a further indication that the pathophysiological process leading to lung impairment may differ between men and women.

【 授权许可】

Unknown   
© Gislason et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.