Genetic diversity of the 2013–14 human isolates of influenza H7N9 in China

BMC Infectious Diseases

Research Article

Elodie Ghedin¹  Yingmu Cai²  Amber Farooqui³  Weibin Chen³  Tiansheng Zeng³  Yisu Liu³  Li Zhang³  Ting Su³  David J Kelvin⁴  Alberto J Leon⁴  Xibin Fang⁵  Weihong Chen⁵  Suwu Wu⁵  Linxi Huang⁶  Pengzhou Lin⁶  Huachen Zhu⁷  Yi Guan⁷ 

[1] Department of Biology, Center for Genomics and Systems Biology, Global Institute of Public Health, New York University, New York, USA;Department of Laboratory Medicine, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China;Division of Immunology, International Institute of Infection and Immunity, Shantou University Medical College, 22 Xinling Road, 515041, Shantou, Guangdong, China;Division of Immunology, International Institute of Infection and Immunity, Shantou University Medical College, 22 Xinling Road, 515041, Shantou, Guangdong, China;Division of Experimental Therapeutics, University Health Network, Toronto, Ontario, Canada;Intensive Care Unit, Shantou Central Hospital, Shantou, Guangdong, China;Intensive Care Unit, the First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China;Joint Influenza Research Centre (SUMC/HKU), Shantou University Medical College, Shantou, China;State Key Laboratory of Emerging Infectious Diseases/Centre of Influenza Research, School of Public Health, The University of Hong Kong, Hong Kong, SAR, China;

关键词: Avian Influenza;    H7N9 Virus;    Human Case;    Influenza H7N9;    Influenza H7N9 Virus;   

DOI  :  10.1186/s12879-015-0829-8

 received in 2014-09-29, accepted in 2015-02-11,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundInfluenza H7N9 has become an endemic pathogen in China where circulating virus is found extensively in wild birds and domestic poultry. Two epidemic waves of Human H7N9 infections have taken place in Eastern and South Central China during the years of 2013 and 2014. In this study, we report on the first four human cases of influenza H7N9 in Shantou, Guangdong province, which occurred during the second H7N9 wave, and the subsequent analysis of the viral isolates.MethodsViral genomes were subjected to multisegment amplification and sequenced in an Illumina MiSeq. Later, phylogenetic analyses of influenza H7N9 viruses were performed to establish the evolutionary context of the disease in humans.ResultsThe sequences of the isolates from Shantou have closer evolutionary proximity to the predominant Eastern H7N9 cluster (similar to A/Shanghai/1/2013 (H7N9)) than to the Southern H7N9 cluster (similar to A/Guangdong/1/2013 (H7N9)).ConclusionsTwo distinct phylogenetic groups of influenza H7N9 circulate currently in China and cause infections in humans as a consequence of cross-species spillover from the avian disease. The Eastern cluster, which includes the four isolates from Shantou, presents a wide geographic distribution and overlaps with the more restricted area of circulation of the Southern cluster. Continued monitoring of the avian disease is of critical importance to better understand and predict the epidemiological behaviour of the human cases.

【 授权许可】

Unknown   
© Farooqui et al.; licensee BioMed Central. 2015. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.