Report of depressive symptoms on waiting list and mortality after liver and kidney transplantation: a prospective cohort study

BMC Psychiatry

Research Article

Didier Samuel¹  Denis Castaing²  Caroline Barry³  Emmanuelle Corruble⁴  Bernard Charpentier⁵  Antoine Durrbach⁵  Bruno Falissard⁶  Philippe Lang⁷  Isabelle Varescon⁸ 

[1] Head of the hepatology department of Paul Brousse University Hospital, Assistance Publique-Hopitaux de Paris, France;Head of the surgery department of Paul Brousse University Hospital, Assistance Publique-Hopitaux de Paris, France;INSERM U 669, Bicetre University Hospital, Assistance Publique-Hopitaux de Paris, 94275, Le Kremlin Bicêtre, France;INSERM U 669, Paris XI University, Psychiatry Department of Bicetre University Hospital, Assistance Publique-Hopitaux de Paris, 94275, Le Kremlin Bicêtre, France;INSERM U542, Nephrology Department of Bicetre University Hospital, Assistance Publique-Hopitaux de Paris, France;INSERM U669, Paris XI University, Department of Biostatistics and Public Health, Paul Brousse Hospital, Assistance Publique-Hôpitaux de Paris, 94800, Villejuif, France;Nephrology Department of Creteil University Hospital, Assistance Publique-Hopitaux de Paris, France;Paris V University, Hepatology and Surgery department of Paul Brousse University Hospital, France;

关键词: depressive symptoms;    self-assessment;    transplantation;    liver;    kidney;    outcome;   

DOI  :  10.1186/1471-244X-11-182

 received in 2011-04-12, accepted in 2011-11-21,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundLittle research has explored pre-transplantation psychological factors as predictors of outcome after liver or kidney transplantation. Our objective is to determine whether report of depressive symptoms on waiting list predicts outcome of liver and kidney transplantation.MethodsPatients on waiting list for liver or kidney transplantation were classified for report or non-report of depressive symptoms on waiting list. 339 were transplanted 6 months later on average, and followed prospectively. The main outcome measures were graft failure and mortality 18 months post-transplantation.ResultsAmong the 339 patients, 51.6% reported depressive symptoms on waiting list, 16.5% had a graft failure and 7.4% died post-transplantation.Report of depressive symptoms on waiting list predicted a 3 to 4-fold decreased risk of graft failure and mortality 18-months post-transplantation, independently from age, gender, current cigarette smoking, anxiety symptoms, main primary diagnosis, UNOS score, number of comorbid diagnoses and history of transplantation. Data were consistent for liver and kidney transplantations. Other baseline predictive factors were: for graft failure, the main primary diagnosis and a shorter length since this diagnosis, and for mortality, older age, male gender and the main primary diagnosis.ConclusionFurther studies are needed to understand the underlying mechanisms of the association between report of depressive symptoms on waiting list and decreased risk of graft failure and mortality after transplantation.

【 授权许可】

CC BY   
© Corruble et al; licensee BioMed Central Ltd. 2011