Exclusive intraoperative radiotherapy for invasive breast cancer in elderly patients (>70 years): proportion of eligible patients and local recurrence-free survival

BMC Surgery

Research Article

Hélène Charitansky¹  Delphine Hudry²  Pierre Gimbergues³  Christelle Faure⁴  Sylvie Giard⁵  Paul Azuar⁶  Richard Villet⁷  Christine Tunon de Lara⁸  Jean Remy Garbay⁹  Sophie Knight^1,10  Marie Bannier^1,11  Amira Ziouèche^1,11  Eric Lambaudie^1,11  Mathieu Minsat^1,11  Agnès Tallet^1,11  Michel Resbeut^1,11  Monique Cohen^1,11  Gilles Houvenaeghel^1,11  François Dravet^1,12 

[1] Centre Claudius Regaud, Toulouse, France;Centre Georges François Leclerc, Dijon, France;Centre Jean Perrin, Clermont Ferrand, France;Centre Léon Bérard, Lyon, France;Centre Oscar Lambret, Lille, France;Hôpital de Grasse, Grasse, France;Hôpital des Diaconesses, Paris, France;Institut Bergonié, Bordeaux, France;Institut Gustave Roussy, Villejuif, France;Institut Paoli Calmettes, 232 Boulevard de Sainte-Marguerite, 13009, Marseille, France;CRCM, Marseille, France;Institut Paoli Calmettes, 232 Boulevard de Sainte-Marguerite, 13009, Marseille, France;CRCM, Marseille, France;Aix Marseille Université, Marseille, France;Institut René Gauducheau, Nantes, France;

关键词: Breast cancer;    Elderly patients;    Intraoperative radiotherapy;   

DOI  :  10.1186/s12893-016-0191-9

 received in 2016-07-23, accepted in 2016-11-04,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundTo estimate the proportion of elderly patients (>70 years) with breast cancer eligible for an Exclusive IntraOperative RadioTherapy (E-IORT) and to evaluate their local recurrence-free survival rate.MethodsThis retrospective study examining two cohorts focuses on patients over 70 years old: a multi-centric cohort of 1411 elderly patients and a mono-centric cohort of 592 elderly patients. All patients underwent conservative surgery followed by external radiotherapy for T0-T3 N0-N1 invasive breast cancer, between 1980 and 2008.ResultsWithin each cohort two groups were identified according to the inclusion criteria of the RIOP trial (R group) and TARGIT E study (T group). Each group was divided into two sub-groups, patients eligible (E) or non-eligible (nE) for IORT. The population of patients that were eligible in the TARGIT E study but not in the RIOP trial were also studied in both cohorts. The proportion of patients eligible for IORT was calculated, according to the eligibility criteria of each study. A comparison of the 5-year local or locoregional recurrence-free survival rate between eligible vs non-eligible patients was made.In both cohorts, the proportion of patients eligible according to the RIOP trial’s eligibility criteria was 35.4 and 19.3%, and according to the TARGIT E study criteria was 60.9 and 45.3%.The 5-year locoregional recurrence-free survival rate was not significantly different between RE and RnE groups, TE and TnE groups. In both cohorts RE and (TE-RE) groups were not significantly different.ConclusionsOur results encourage further necessary studies to define and to extend the eligibility criteria for per operative exclusive radiotherapy.

【 授权许可】

CC BY   
© The Author(s). 2016