Antimicrobial activities of the methanol extract and compounds from Artocarpus communis (Moraceae)

BMC Complementary and Alternative Medicine

Research Article

Jean P Dzoyem¹  Victor Kuete¹  Berhanu M Abegaz²  Patrick Y Ango³  Gilbert DWF Kapche³  Arlette G Wouking⁴  Ghislain W Fotso⁴  Bonaventure T Ngadjui⁴ 

[1] Department of Biochemistry, Faculty of Science, University of Dschang, Cameroon;Department of Chemistry, Faculty of Science, University of Botswana, Private Bag 00704, Gaborone, Botswana;Department of Chemistry, Higher Teachers' Training College, University of Yaoundé I, Cameroon;Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon;

关键词: Minimal Inhibitory Concentration;    Crude Extract;    Pacific Island;    Sitosterol;    Stem Bark;   

DOI  :  10.1186/1472-6882-11-42

 received in 2011-02-11, accepted in 2011-05-25,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundArtocarpus communis is used traditionally in Cameroon to treat several ailments, including infectious and associated diseases. This work was therefore designed to investigate the antimicrobial activities of the methanol extract (ACB) and compounds isolated from the bark of this plant, namely peruvianursenyl acetate C (1), α-amyrenol or viminalol (2), artonin E (4) and 2-[(3,5-dihydroxy)-(Z)-4-(3-methylbut-1-enyl)phenyl]benzofuran-6-ol (5).MethodsThe liquid microdilution assay was used in the determination of the minimal inhibitory concentration (MIC) and the minimal microbicidal concentration (MMC), against seven bacterial and one fungal species.ResultsThe MIC results indicated that ACB as well as compounds 4 and 5 were able to prevent the growth of all tested microbial species. All other compounds showed selective activities. The lowest MIC value of 64 μg/ml for the crude extract was recorded on Staphylococcus aureus ATCC 25922 and Escherichia coli ATCC 8739. The corresponding value of 32 μg/ml was recorded with compounds 4 and 5 on Pseudomonas aeruginosa PA01 and compound 5 on E. coli ATCC 8739, their inhibition effect on P. aeruginosa PA01 being more than that of chloramphenicol used as reference antibiotic.ConclusionThe overall results of this study provided supportive data for the use of A. communis as well as some of its constituents for the treatment of infections associated with the studied microorganisms.

【 授权许可】

CC BY   
© Kuete et al; licensee BioMed Central Ltd. 2011