Risk factors, complications and survival after upper abdominal surgery: a prospective cohort study

BMC Surgery

Research Article

K.C. Fearon¹  N. Johns¹  A. Horn²  E. K. Aahlin³  A. Revhaug³  K. Lassen³  G. Tranø⁴  J. A. Søreide⁵ 

[1] Clinical Surgery, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, UK;Department of Abdominal and Emergency Surgery, Haukeland University Hospital, Bergen, Norway;Department of GI and HPB Surgery, University Hospital of Northern Norway, 9038, Tromsø, Breivika, Norway;Institute of Clinical Medicine, University of Tromsø - The Arctic University of Norway, Tromsø, Norway;Department of Gastrointestinal Surgery, St. Olavs Hospital - Trondheim University Hospital, Trondheim, Norway;Department of Gastrointestinal Surgery, Stavanger University Hospital, Stavanger, Norway;Department of Clinical Medicine, University of Bergen, Bergen, Norway;

关键词: Sarcopenia;    Cachexia;    Cancer;    Gastrointestinal;    Hepatopancreatobiliary;    Surgery;   

DOI  :  10.1186/s12893-015-0069-2

 received in 2015-02-20, accepted in 2015-06-26,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundPreoperative weight loss and abnormal serum-albumin have traditionally been associated with reduced survival. More recently, a correlation between postoperative complications and reduced long-term survival has been reported and the significance of the relative proportion of skeletal muscle, visceral and subcutaneous adipose tissue has been examined with conflicting results. We investigated how preoperative body composition and major non-fatal complications related to overall survival and compared this to established predictors in a large cohort undergoing upper abdominal surgery.MethodsFrom 2001 to 2006, 447 patients were included in a Norwegian multicenter randomized controlled trial in major upper abdominal surgery. Patients were now, six years later, analyzed as a single prospective cohort and overall survival was retrieved from the National Population Registry. Body composition indices were calculated from CT images taken within three months preoperatively.ResultsPreoperative serum-albumin <35 g/l (HR = 1.52, p = 0 .014) and weight loss >5 % (HR = 1.38, p = 0.023) were independently associated with reduced survival. There was no association between any of the preoperative body composition indices and reduced survival.Major postoperative complications were independently associated with reduced survival but only as long as patients who died within 90 days were included in the analysis.ConclusionsOur study has confirmed the robust significance of the traditional indicators, preoperative serum-albumin and weight loss. The body composition indices did not prove beneficial as global indicators of poor prognosis in upper abdominal surgery. We found no association between non-fatal postoperative complications and long-term survival.

【 授权许可】

CC BY   
© Aahlin et al. 2015